2012, Number 2
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Rev Cub de Toxicol 2012; 1 (2)
Genotoxicity of a type of acrylamide derived from the hydrolysis of n-butyl cyanoacrylate
Cañizares GME, González NB, Torres AMA
Language: Spanish
References: 9
Page:
PDF size: 185.39 Kb.
ABSTRACT
Introduction: alkyl cyanoacrylates are acrylic monomers highly used as adhesives. Recently it has been demostrated by chemical methods that n-butyl cyanoacrylate is hydrolyzed to a specific acryl amide when it is in contact with tissues. The identified structure accounts for the formation of ionic and covalent bonds with the biological structure as well as the absorption of the product by tissues.
Objective: to determine the genotoxicity of n butyl cyanoacrylate.
Methods: a micronuclei test was conducted by dermal route in the femur of 30 NMRI mice at a limit dose of 2 000 mg/kg using acrylamide as positive control and the non
treated animals as negative control.
Results: the test was positive after 48 hours and confirmed the damage to the genetic material as a consequence of its chemical structure.
Conclusions: the corroborated genotoxicity of the acrylamide type as a consequence of the hydrolysis of n butyl cyanoacrylate could have repercussions over environmental criteria established for the use of glues and other substances containing this compound.
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