2013, Number 1
RCU 2013; 2 (1)
Hiperaldosteronismo primario por adenoma suprarrenal con cuerpos de espironolactona. Presentación de un caso
López ML, Bacallao MR, González NL, Rodríguez López-Calleja CA, De La Concepción GOM, Matos TM
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ABSTRACTAldosterone-producing adenomas (Conn's syndrome) are responsible for most cases of primary aldosteronism. Observing small benign tumors, usually well defined, single and less than two cm, located at the adrenal cortex. We report a case of a 43 years old man with hypertension unsensitive to medical treatment of four years of evolution, during the last year started with muscle weakness and cramps. In the ionogram was found hypokalemia and a left adrenal tumor on CT scan. In addition we have found a marked elevation of plasma aldosterone, plasma renin activity ratio, hence primary aldosteronism is diagnosed secondary to Conn's tumor. Laparoscopic adrenalectomy was performed and the histological study of the anatomical piece showed the presence of a mixed cortical adenoma. On the electron microscopy study there were cytoplasmic eosinophilic inclusions corresponding to spironolactone bodies. It is the first time that spironolactone bodies are described in Cuban medical literature.