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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2014, Number 1

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Rev Biomed 2014; 25 (1)

The locomotor response during a forced swimming test in a novel circular corridor environment as a predictor for changes in antidepressant indices in female Wistar rats

Flores-Serrano AG, Zaldívar-Rae J, Salgado-Burgos H, Pineda-Cortés JC

Language: Spanish
References: 29
Page: 3-15
PDF size: 340.88 Kb.


ABSTRACT

Introduction. Antidepressant drugs differentially modulate behaviors used as depressive indices in rats with different locomotor responses when faced with a new stressful environment.
Objective. To evaluate in the forced swimming test (PNF), female Wistar rats selected according to the distance traveled in the circular corridor test (CC).
Materials and Methods. We compared the performance in the forced swimming test a group of rats detected in below the 34th percentile in the distribution of their locomotor responses, classified as "LR", with another group "HR", detected above the 66th percentile in the same distribution in the CC.
Results. On average, 40 rats made 183 ± 9 crossings (median 184) in the CC. LR rats produced 125 ± 8 crossings (median 120, n = 9). While rats HR produced 229 ± 10 crossings (median 216, n = 6). In 20 rats evaluated in the FST a week after CC, the immobility time (IT) was increased (p ‹0.01) and climbing time (CT) decreased (p ‹0.01) significantly between the two days with no change in swimming time (ST; paired t-test). However, when this group HR and LR rats were evaluated separately for rats LR now only reduced the ST. IT increased and CT declined for HR rats. The number of crosses made by LR rats, but not for the HR, showed correlation with IT and CT.
Conclusions. The differential response to a novel environment of Wistar rats female predicts their performance on FST.


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