2014, Number 07
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ABSTRACTBackground. Oxytocin is a well known drug most commonly used in obstetrics for induction or augmentation of labor. Due to its essential role in labor, and the overall effect in the body, oxytocin must be deeply understood by all obstetricians who use it and prescribe it. There is relevant data listed about oxytocin and has reviewed the evidence in 31 full text articles of indexed journals between 1999 and 2013. In search engines like MEDLINE, MedicLatina, PUBMED, Wolters Kluwer Healt, with keywords like: oxytocin, oxytocin receptor, oxytocin vasopressin, oxytocin postpartum, oxytocin review, oxytocin labor, oxytocin reléase. The best evidence from the literature based on the methodology they used is included. The word oxytocin comes from the Greek words ωχνξ, τoχoxξ, which means “swift birth”. It is synthesized in the paraventricular and supraoptic nuclei of the hypotalamus is mainly released from the neurohypophysis and nerve terminals. It travels from the brain to the heart and the whole body, activating or modulating a wide range of functions and emotions. Mainly cause myometrial contractions and myoepithelial cells of the breast for milk ejection. Its adverse effects polipépare dose-related. No one knows exactly the minumum and maximum dose of oxytocin. More research is needed about central and peripheral receptors, coupled with the use to which they currently gives to agonists and antagonists of oxytocin and its receptor. As of 2013, the documented adverse effects to date have been undervalued.
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Magon N, Kalra S. The orgasmic history of oxytocin: Love, lust and labor. Indian J Endocrinol Metab 2011;15:156- 161.
Stormshak F. Biochemical and endocrine aspects of oxytocin production by the mammalian corpus luteum. Reprod Biol Endocrinol 2003;1:1-6.
Forsyth AI, Neville CM. Introduction: the myoepithelial cell and milk letdown; Entrance to the multifunctional role of oxytocin. J Mammary Gland Biol Neoplasia 2009;14:221- 222.
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Clark SL, Simpson KR, Knox GE, et al. Oxytocin: new perspectives on an old drug. Am J Obstet Gynecol 2009;200:35. e1-35.e6.
Liccardi G, Biló MB, Mauro C, Salzillo A, Piccolo A. Oxytocin: an unexpected risk for cardiologic and broncho-obstructive effects, and alergic reaction in susceptible delivering women. Multidiscip Respir Med 2013;8:1-4.
Kubzansky DL, Mendes BW, Appleton A, Block J, Adler KG. Protocol for an experimental investigation of the roles of oxytocin and social support in neuroendocrine, cardiovascular and subjective responses to stress across age and gender. BMC Public Health 2009;9:1-17.
Kramer KM, Yoshida S, Papademetriou E, Cushing SB. The organizational effects of oxytocin on the central express estrogen receptor α and oxytocin in adulthood. BMC Neurosci 2007;8:1-8.
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Chunling L, Weidong W, Sandra NS, Timothy DW, David PB. Molecular Mechanisms of Antidiuretic Effect of Oxytocin. J Am Soc Nephrol 2008;19:225-232.
Fonseca L, Wood CH, Lucas MJ, Ramin MS, Phatak D. Randomized trial of preinduction cervical ripening: Misoprostol vs oxytocin. Am J Obstet Gynecol 2008;199:305.e1-305.e5
Diven CL, Rochon LM, Google J, Eid S, Smulian CJ. Oxytocin discontinuation during active labor in women who undergo labor induction. Am J Obstet Gynecol 2012;207:471.e1-8.
Prasad MR, Funai E. Oxytocin use during active labor, too much of a good thing? Am J Obstet Gynecol 2012;439-440.
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Cahill AG, Waterman BM, Stamilio DM. Higher maximum doses of oxytocin are associated with an unacceptably high risk for uterine rupture in patients attempting vaginal birth after cesarean delivery. Am J Obstet Gynecol 2008;199:32. e1-32.e5.
Nachum Z, Garmi G, Kadan Y, Zafran N, Salim R. Comparison between amniotomy, oxytocin or both augmentation of labor in prolonged latent phase: a randomized controlled trial. Reprod Biol Endocrinol 2010;8:136.
Holleboom CAG, Eyck JV, Koenen SV, Kreuwel IAM. Carbetocin in comparison with oxytocin in several dosing regimens for the prevention of uterine atony after elective caesarean section in the Netherlands. Arch Gynecol Obstet 2013;287:1111-1117.