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2014, Number 2

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Rev Hematol Mex 2014; 15 (2)

Trichosporon asahii pneumonia in a patient with acute graft-versus-host disease

Labastida-Mercado N, Galindo-Becerra LS, Schcolnik-Cabrera A, Fernández-Lara D, Sánchez-Sosa S, Ruiz-Argüelles GJ
Full text How to cite this article

Language: Spanish
References: 12
Page: 80-83
PDF size: 411.67 Kb.


Key words:

acute graft-versus-host disease, pneumonia, Trichosporon asahii.

ABSTRACT

Trichosporon asahii is a yeast usually found as a part of the normal microbiota on skin and gastrointestinal tract, with a pathogenic potential if the host is immunocompromised. We report a case of a median-age male patient with diagnosis of acute myelogenous leukemia who came to our clinic, where he began the Mexican non-ablative conditioning regimen to start a stem cell transplantation from his HLA-compatible female sibling, but complicates with graft-versus-host disease which was successfully treated, and then ended with a fatal pneumonic fungal infection due to T. asahii.


REFERENCES

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  2. Da Silva G, Ubatuba R, Guazzelli L, et al. Infección nosocomial por Trichosporon asahii: revisión clínica de 22 casos. Rev Iberoam Micol 2006;23:85-89.

  3. Hazirolan G, Canton E, Sahin S, et al. Head-to-head comparison of inhibitory and fungicidal activities of fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole against clinical isolates of Trichosporon asahii. Antimicrob Agents Chemother 2013;57:4841-4847.

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  9. Matsue K, Uryu H, Koseki M, et al. Breakthrough trichosporonosis in patients with hematological malignancies receiving micafungin. Clin Infect Dis 2006;42:753-757.

  10. Fernández-Lara D, Domínguez-Cid M, Ruiz-Delgado G. Enfermedad de injerto contra huésped pulmonar crónica postrasplante de células hematopoyéticas alogénicas. Aspectos diagnósticos y terapéuticos. Rev Hematol Mex 2013;14:138-144.

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Rev Hematol Mex. 2014;15