Ramírez AAK, Escalante GC

Language: Spanish
References: 20
Page: 455-461
PDF size: 183.95 Kb.

ABSTRACT

Endometriosis is a benign chronic inflammatory disease characterized by the presence of endometrial tissue outside the uterine cavity, typically within the pelvis. Since initial descriptions of the disease, several theories have been proposed to explain the genesis of endometriosis; however none can adequately expound the pathophysiology of the disease. Because of that reason, recent studies on endometriosis have focused on immunological and endocrinological events that are part of the pathophysiology of endometriosis. Studies have found that the abnormal immune response of women with endometriosis is mainly characterized by an imbalance between the action of M1 and M2 type macrophages and such imbalance triggers a series of events that culminate in the development of the disease.

REFERENCES

1. Acien P, Velasco I. Endometriosis: A disease that remains enigmatic. ISRN Obstet GYnecol. 2013; 2013: Article ID 242149, 12 pages.

2. Augoulea A, Alexandrou A, Creatsa M, Vrachnis N, Lambrinoudaki I. Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress. Arch Gynecol Obstet. 2012; 286: 99-103.

3. Ayala R, Mota M. Endometriosis: fisiopatología y líneas de investigación (segunda parte). Ginecol Obstet Mex. 2008; 76: 549- 557.

4. Boron W, Boulpaep E. Medical Physiology: A cellular and molecular approach. 2th Ed. Philadelphia: Elsevier; 2008.

5. Brosens I, Brosens J. Endometriosis, Eur J Obstet Gynecol Reprod Biol. 2000; 90: 159-164.

6. Bulun S. Mechanisms of disease, endometriosis. N Engl J Med. 2009; 360: 268-279.

7. Burney R, Giudice L. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012; 98: 511-519.

8. Gazvani R, Templeton A. New considerations for the pathogenesis of endometriosis. Int J Gynaecol Obstet. 2002;76: 117-126.

9. Gazvani R, Templeton A. Peritoneal enviorement, cytokines and angiogenesis in the pathophysiology of endometriosis. Reproduction. 2002; 123: 217-226.

10. Giudice L. Endometriosis. The Lancet 2004; 364: 1789-1799.

11. Jensen J, Coddington C. Envolving Spectrum: The Pathogenesis of Endometriosis. Mayo Clinic OB/ GYN clinical reviews. 2012; 53: 370-388.

12. Krikun G. Endometriosis, Angiogenesis and Tissue Factor. Scientifica. 2012; 2012: Article ID 306830, 10 pages.

13. Maia H, Haddad C, Casoy J. Correlation between aromatase expression in the eutopic endometrium of syntomatic patients and the presence of endometriosis. Int J Womens Health. 2012; 2012: 61-65.

14. Matarese G, De Placido G, Nikas Y, Alviggi C. Pathogenesis of endometriosis: natural immunity dysfunction or autoinmune disease. Trends Mol Med. 2003; 9: 223-228.

15. Nap A, Groothuis P, Demir A, Evers J, Dunselman G. Pathogenesis of endometriosis. Best Pract Res Clin Obstet Gynaecol. 2004; 18: 233-244.

16. Saad A. Endometriosis. Obstetric, Gynaecology and Reproductive Medicine. 2008; 18: 126-133.

17. Szyllo K, Tchorzewski H, Banasik M, Glowacka E,Lewkowicz P, Kamer-Bartosinska A. The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis. Mediators Inflamm. 2003; 12: 131-138.

18. Vinatier D, Orazi G, Cosson M, Dufour P. Theories of endometriosis. Eur J Obstet Gynecol Reprod Biol. 2001; 96: 21-34.

19. Vigano P, Parazzini F, Somigliana E, Vercellini P.Endometriosis: epidemiology and aetiological factors. Best Pract Res Clin Obstet Gynaecol. 2004; 18: 177-200.

20. Ziegler D, Borghese B, Chapron C. Endometriosis and infertility: pathophysiology and management. The Lancet. 2010; 376: 730-738