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Academia Mexicana de Neurología, A.C.

2014, Number 2

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Rev Mex Neuroci 2014; 15 (2)

Neuropsychological profile in a case of multicenter germinoma

Menéndez-Narváez RA

Language: Spanish
References: 32
Page: 101-111
PDF size: 272.17 Kb.


ABSTRACT

Introduction: CNS germinomas are primary tumors located in the pineal region, suprasellar compartment and third ventricle. They cause pituitary and hypothalamic endocrine alterations, behavioral disorders and hemianopia. These tumors are treated with surgery, radiotherapy and/or chemotherapy, which favor morphological and/or functional changes in the CNS, including neuropsychological impairment (slow cognitive processing, IQ decline, attention deficits, altered motor skills, memory, verbal fluency, sequential processing, and academic skills).
Case Report: A patient with multicenter germinoma in the sellar region was evaluated. A test searching for alterations in most cognitive functions (NEUROPSI) was applied, also a general test of intelligence an IQ (WISC-IV), and specific tests to evaluate memory (TAVECI and REY), language (Boston test), and executive functions (D2, 5 digits test, tower of London and classification test of WISCONSIN cards). The patient presented disturbances in the attention control process, memory, language, learning process and executive function (planning, organization, inhibition, self monitoring, and processing speed).
Conclusion: The disturbances are consistent with thalamic dysfunctions, front-temporal circuit, frontal dorso-lateral cortex and angular gyrus.


REFERENCES

  1. Chico-Ponce de León F, Castro-Sierra E, Perezpeña-Diazconti M, et al. Tumores Intracraneanos del niño. Bol Med Hosp Infant Mex 2006; 63: 369-81.

  2. Jennings M, Gelman R, Hochberg F. Intracranial germ cell tumors: natural history and pathogenesis. J Neurosurg 1985; 63: 155-67.

  3. Escalona-Zapata J. Tumores del Sistema Nervioso Central. Editorial Complutense; 1996.

  4. Kleihues P, Cavenee W. Pathology and Genetics of Tumors of the Nervous System. The World Health Organization classification of tumours. Lyon: IARC Press, 2000.

  5. García S, Salinas C, Tena M, Gómez M, Rembao D. Tumores germinales del sistema nervioso central. Estudio clínico, patológico e inmunohistoquímico de 24 casos. Patología 2008; 46: 228-36.

  6. Villarejo F, Martínez J. Tumores cerebrales en niños. Pediatr Integral 2008; XII: 577-83.

  7. González-Meneses A. Bases genéticas y moleculares de los tumores infantiles. Pediatr Integral 2012; XVI: 434-40.

  8. Walsh J, Zimmier S, Perdue M. Role of viruses in the induction of primary intracranial tumors. Neurosurgery 1982; 10: 643-62.

  9. Kaye AH, González MF. Biology of brain tumors. In: Crockard A, Hayward R, Hoff JT (eds.). Neurosurgery, the scientific basis of clinical practice. Oxford: Blackwell Scientific Publications; 1992, p. 527-43.

  10. Einhaus SL, Sanford RA. Craniopharyngiomas. In: Albright AL, Pollack IF, Adelson PD (Eds.). Principles and practice of pediatric neurosurgery. New York: Thieme; 1999, p. 545-62.

  11. Davis F, Kupelian V, Freels S, MacCarthy B. Prevalence estimate for primary brain tumors in USA by behavior and mayor histology groups. Neuro-Oncology 2001; 3: 152-8.

  12. Jukich P, MacCarthy B, Surawicz T, Freels S, Davis F. Trend in incidence of primary brain tumor in the United States 1985-1994. Neuro-Oncology 2001; 3: 141-51.

  13. Díaz V, Yáñez A, Ponce C, Villegas R, Pastén J. Tendencia de la mortalidad por tumores cerebrales malignos en Chile: Análisis de tasas. Rev Chil Neuro-Psiquiat 2006; 44: 263-70.

  14. Patchell R, Posner J. Cancer and the Nervous System. Handbook of Psychooncology. Psychological care of the patient with cancer. Oxford: Oxford University Press; 1989, p. 327-41.

  15. Mulhern R, Kovnar E, Langston J, Carter M, Fairclough D, et al. Longterm survivors of leukaemia treated in infancy: Factors associated with neuropsychological status. J Clin Oncol 1992; 10: 1095-102.

  16. Reddick W, White H, Glass J, Wheeler G, Thompson S, et al. Developmental Model Relating White Matter Volume to Neurocognitive Deficits in Pediatric Brain Tumor Survivors. Cancer 2003; 97: 2512-19.

  17. Bernabeu J, Cañete A, Fournier C, López B, Barahona T, et al. Evaluación Rehabilitación Neuropsicológica en Oncología Pediátrica. Psicooncología 2003; 1: 117-34.

  18. García-Pérez J, Pollán M, Boldo E, Pérez-Gómez B, Aragonés, et al. Mortality due to lung, laryngeal and bladder cancer in towns lying in the vicinity of combustion installations. Science of The Total Environment 2009; 407: 2593-602.

  19. Olvera-Manzanilla E, Ruiz-González DS, Platas-De la Mora A, Ochoa- Carrillo FJ, Alvarado-Aguilar S. Aspectos neuropsicológicos de los pacientes con tumores cerebrales. GAMO 2011; 10: 143-9.

  20. Ardila A, Ostrosky F. Diagnóstico del daño cerebral. México: Trillas; 1993. Citado por: Alvarán L, Gómez LA, Aguirre DC, Ortiz LD. Caracterización Neuropsicológica de Pacientes con Glioma tratados en el Instituto de Cancerología de Medellín. Acta Neurol Colomb 2008; 24: 13-23.

  21. Weschler D. Escala Wechsler de Inteligencia para Niños-WISC IVTEA Ediciones; 2007.

  22. Ostrosky-Solís F, Gómez E, Matute E, Roselli M, Ardila A, Pineda D. Batería Neuropsicológica Breve: NEUROPSI. UNAM 1999.

  23. Benedet M, Alejandre M, Pamos A (Test de Aprendizaje Verbal TAVECI). TEA Ediciones.

  24. Goodglass H, Kaplan E. Test de Boston, Evaluación de la afasia y trastornos relacionados. 3ª. Ed. Panamericana; 2009.

  25. Rey A. REY Test de copia y reproducción de memoria de figuras geométricas complejas. TEA Ediciones; 1975.

  26. Brickenkamp R. D2 Test de atención. 2a. Ed. TEA Ediciones; 2004.

  27. Sedó M. Test de los 5 dígitos. TEA Ediciones; 2007.

  28. Culbertson W, Zillmer W. Torre de Londres. 2a. Ed. MHS. 2009.

  29. Heaton R, Chelune G, Talley J, Kay G, Curtiss G. Test de Clasificación de tarjetas de WISCONSIN. TEA Ediciones; 1997.

  30. Goldman-Rakic P, Muly E, Williams, G. D1 receptors in prefrontal cells and circuits. Brain Res Rev 2000; 31: 295-301.

  31. Afifi A, Bergman R. Neuroanatomía Funcional. 2a. Ed. Mc.GrawHill; 2006.

  32. Jenkin D. Long-term survival in children with brain tumors. Oncology 1996; 10: 715-19.




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