Arturo Z, Manuel-Apolinar L

Language: Spanish
References: 7
Page: 104-106
PDF size: 164.56 Kb.

ABSTRACT

Douglas L. Coleman (October 6, 1931 to April 16, 2014) proposed, using rodent experiments, the theory of the existence of a substance in the circulation that regulates the appetite to prevent obesity. Jeffrey M. Friedman identified the gene expressing the substance and named it leptin, which originated in adipose tissue and reached the hypothalamus, where it was recognized by a specific receptor and thus reduced appetite. According to the kind of mutation, the synthesis of either leptin or its receptor could be deleted, inducing hyperphagia, obesity and diabetes. These findings encouraged the possibility to get a treatment for obesity and were the reason why they were granted the Lasker Award in 2010. It is known that Coleman was nominated for the Nobel Prize, but his death now excludes him.

REFERENCES

1. Hummel KP, Dickie MM, Coleman DL. Diabetes, a new mutation in the mouse. Science. 1966; 153 (740): 1127-1128.

2. Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 1973; 9: 294-298.

3. Coleman DL. A historical perspective on leptin. Nat Med. 2010; 16: 1097-1099.

4. The Lasker Foundation celebrates medical advances made with help from model organisms. Dis Model Mech. 2009; 2 (11-12): 532-533.

5. Ushman SN. Leaping for leptin: the 2010 Albert Lasker Basic Medical Research Award goes to Douglas Coleman and Jeffrey M. Friedman. J Clin Invest. 2010; 120 (10): 3413-3418.

6. Manuel-Apolinar L, Zárate A, Hernández-Valencia M. Leptina, hormona del adipocito, regula el apetito y el consumo de energía. Papel en la obesidad y dismetabolismo. Acta Médica Grupo Ángeles. 2012; 10 (3): 154-156.

7. Basurto L, Saucedo R, Ochoa R, Hernández M, Zárate A. Terapia de reemplazo hormonal con estradiol transdérmico disminuye los niveles de insulina-cortisol y lipoproteínas en mujeres posmenopáusicas. Ginec Obstet Mex. 2002; 70: 491-495.