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Acta Ortopédica Mexicana

ISSN 2992-8036 (Electronic)
ISSN 2306-4102 (Print)
Órgano Oficial del Colegio Mexicano de Ortopedia y Traumatología
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2014, Number 3

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Acta Ortop Mex 2014; 28 (3)

Effectiveness of two intraarticular drugs in patients with knee arthrosis. polymerized collagen versus hylan GF 20

Arteaga-Solís JR, Negrete-Corona J, Chávez-Hinojosa E, Díaz-Martínez B
Full text How to cite this article

Language: Spanish
References: 9
Page: 164-167
PDF size: 129.83 Kb.


Key words:

arthrosis, knee, collagen, nillan, intrarticular.

ABSTRACT

The purpose of osteoarthrosis treatment is to improve patient’s pain and quality of life. Non-steroidal anti-inflammatory drugs are the first choice but their effectiveness is questionable due to the risk of secondary gastric disease and renal failure. Intra-articular drugs are a safe and effective alternative to improve symptoms and function; they may delay surgery but we don’t know if they are disease modifying. Our objective was to compare knee function and pain in patients with osteoarthrosis until treatment is finished. Our hypothesis is that there is no difference in the results of both groups. Material and methods: A prospective, simple, randomized non blinded trial where we studied two groups of patients with knee osteoarthrosis. Group 1 was treated with Collagen PVP and Group 2 received hylan GF-20. We gave patients a subjective questionnaire of the International Knee Committee IKDC and pain was measured using the visual analog scale at the beginning of treatment, after one month and after three months. Results: Decrease in pain measured with the visual analog scale is statistically significant in both groups, however, when comparing both groups we did not find differences. The results of the IKDC were the same in both groups, there was no difference except in baseline measurements and in the final result.


REFERENCES

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  2. Furuzawa-Carballeda J, et al: Effect of polymerized-type I collagen in knee osteoarthritis. II. In vivo study. Eur J Clin Invest. 2009; 39: 598-606.

  3. Peña Ayala AH, et al: Prevalencia y factores de riesgo de la osteoartritis. Reumatol Clin. 2007; 3 (Supl 3): S6-12.

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  5. Forster MC, Straw R: A prospective randomized trial comparing intra-articular Hyalagan injection and arthroscopic washout for knee osteoarthritis. Knee. 2003; 10: 291-293.

  6. Almazán A, Cruz F, Pérez F, Bravo C, Ibarra C: Tratamiento artroscópico de la osteoartritis: rodilla y hombro. Reumatol Clin. 2007; 3 (Supl 3): S44-49.

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  8. Moreland LW, Arnold WJ, Saway A, Savory C, Sikes D: Efficacy and safety of intrarticular hylan GF-20 (Synvisc), a viscoelastic derivative of hyaluronan, in patients with osteoarthritis of the knee. Arthritis Rheum. 1993; 36: B143.

  9. Leopold SS, Redd BB, Warme WJ, Wherle PA, Pettis PD, Shott S: Corticosteroid compared with hyaluronic acid injections for the treatment of osteoarthritis of the knee. A prospective, randomized trial. J Bone Joint Surg Am. 2003; 85:1197-203.




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Acta Ortop Mex. 2014 May-Jun;28