2013, Number 5
Effects of oral Polypodium leucotomos extract as adjuvant in the treatment of vitiligo with narrow-band UVB
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ABSTRACTOne of the considered highly efficient treatments against vitiligo is narrow band UV-B phototherapy, but their adverse effects limit its use. On the other hand, Polypodium leucotomos with photoimmunoprotection and antioxidant actions decrease the phototoxicity of the ultraviolet radiation. The objective of this study is to determine if P. leucotomos: blocks or increase the therapeutic effect of the UV-B narrow band. This is a double blind clinical study that involves patients with vitiligo which UV-B narrow band phototherapy has been prescribed. Thirteen patients with vitiligo were enrolled to the study. The mean of age was 27 ± 12. The mean of the number of spots was 8 ± 6. The mean of the evolution time was 8 ± 10 months. From the thirteen patients, five patients (38%) dropped out the research and 8 (62%) finished it. From the 8 patients who finished the study, 4 received P. leucotomos (grup A) and 4 received placebo (grup B). The group A started with a mean of depigmentation area of 35 ± 21%, and finished with a mean of depigmentation of 16 ± 17%. The group B started with a depigmentation mean of 26 ± 13% and finished with 6 ± 4%. We believe that we could employ the P. leucotomos, combined with any ultraviolet therapy due to its therapeutic effects are not affected, and it adds the benefit to diminish the phototoxicity, specially in vitiligo because P. leucotomos would contribute with its immunomodulating actions.
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