Gil HGE, García ÁJ, Díaz ACY

Language: Spanish
References: 12
Page: 125-128
PDF size: 180.51 Kb.

ABSTRACT

Introduction: Nowadays laparoscopic cholecysctectomy (LC) is the most practiced surgical technique and the gold standard treatment for cholelithiasis all over the world; as opposed to open cholecysctectomy (OC), the relationship between metabolic response and LC has not been completely studied. There are several types of biomarkers involved in metabolic response to trauma; the purpose of this study is to compare the differences between LC and OC in regards to inflammatory biomarkers. Object: Evaluate through serological testing the metabolic response to trauma (MRT), with a reproducible model of the same procedure (cholecystectomy), open versus laparoscopic approach. Material and methods: Two groups, OC and LC, were compared using serological biomarkers cortisol, C reactive protein (CRP) and erythrocyte sedimentation rate (ESR), taken before surgery, right after surgery and 6 hours after surgery. Results: Group 1 (LC): n = 19 (5 men, 13 women), Group 2 (OC): n = 18 (4 men, and 14 women). Cortisol (p = 0.0018) and CRP (p = 0.004) showed to be statistically significant lower in group 1; while ESR showed no significant difference between both groups (p = 0.461). Discussion: This study shows that the laparoscopic approach in cholecystectomy elicits less metabolic response, as compared to an open procedure, demonstrated by using acute phase reactants; in addition to other benefits of the laparoscopic approach that have been widely studies before, such as a reduction in recovery time, faster reincorporation to daily activities, less use of pain killers and lower incidence of surgical site infection.

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