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Revista de Especialidades Médico-Quirúrgicas

Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
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2014, Number 4

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Rev Esp Med Quir 2014; 19 (4)

Conservative medical management of meconium ileus in extreme premature neonate

Domínguez-Morales J, Orozco-Chávez EG, Arce-García IE
Full text How to cite this article

Language: Spanish
References: 8
Page: 507-511
PDF size: 692.23 Kb.


Key words:

Meconium ileus, cystic fibrosis, meconium.

ABSTRACT

Meconium ileus is a common cause of neonatal intestinal obstruction due to accumulation of inspissated meconium in terminal ileum and/ or colon. It is frequently present in preterm new borns and only occurs in 10-20% of cystic fibrosis patients. Clinical manifestations include vomiting, abdominal distension, palpable meconium, delayed passage of stools.
Case report: Newborn of 28.4 gestational weeks and 930 g of birth weight. At 8 days of extrauterine life presents important abdominal distention and abnormalities in stool passage. Secondary meconium ileus is diagnosed by clinical and radiographic suspicion and managed with fasting, total parenteral nutrition, antibiotics, rectal stimulation, and 5 ml/kg twice a day acetylcysteine enemas, recovering without complications after 8 days of treatment.
Conclusions: Simple meconium ileus is a frequently observed condition in preterm newborns that can be treated with twice a day acetylcysteine enemas.


REFERENCES

  1. Carlyle BE, Borowitz DS, Glick PL. A review of pathophysiology and management of fetuses and neonates with meconium ileus for the pediatric surgeon. Journal of Pediatric Surgery 2012;47:772–781.

  2. Gorter RR, Karimi A, Sleeboom Chr, et al. Clinical and genetic characteristics of meconium ileus in newborns with and without cystic fibrosis. J Pediatr Gastroenterol 2010;50:569–572.

  3. Kubota A, Shiraishi J, Kawahara H, Okuyama H, Yoneda A, Nakai H, et al. Meconium-related ileus in extremely low-birthweight neonates: Etiological considerations from histology and radiology. Pediatrics International 2011;53:887–891.

  4. Garza-Cox S, Keeney SE, Angel CA, Thompson LL, Swischuk LE. Meconium Obstruction in the Very Low Birth Weight Premature Infant. Pediatrics 2004;114: 285-290.

  5. Veyrac C, Baud C, Prodhomme O, Saguintaah O, Couture A. US assessment of neonatal bowel (necrotizing enterocolitis excluded). Pediatr Radiol 2012;42:107–114.

  6. Wolfgang R, Bernhard R, Gerhard P, Heinz H, Berndt U, Wilhelm M. Delayed Meconium Passage in Small vs. Appropriate for Gestational Age Preterm Infants: Management and Short-Term Outcome. Iran J Pediatr 2013;23:8-12.

  7. Karimi A, Gorter RR, Sleeboom Chr, Kneepkens CMF, Heij HA. Issues in the management of simple and complex meconium ileus. Pediatr Surg Int 2011;27:963– 968.

  8. Fakhoury K, Durie PR, Levinson H. Meconium ileus in the absence of cystic fibrosis. Arch Dis Child 1992;67:1204– 1206.




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Rev Esp Med Quir. 2014;19