2014, Number 2
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ABSTRACTRationale: Selenium is an important part of the antioxidant defense systems of the body. Diminished values of serum selenium might be associated with an increased morbimortality. Objective: To determine the prevalence of hyposelenemia among patients assisted at the Critical Care Polyvalent Unit, and to assess the influence of this condition upon evolution of patient and unit´s length of stay. Material and method: Serum concentration of selenium was measured by means of mass spectrometry in samples of sera retrieved from 58 patients (Males: 48.2%; Ages › 60 years: 38.9%; APACHE II score ≥ 14: 46.3%). Hyposelenemia was established with serum selenium ‹ 80 µg.dL-1. Nature and strength of association between hyposelenemia and selected demographic, clinical and sanitary predictors were estimated. Results: Hyposelenemia was present in 55.6% of the study serie. Hyposelenemia was independent from proposed predictors. However, hyposelenemia prevailed in patients with high APACHE II scores, multiple organ dysfunction, and infections; and those who died during their admission to the unit. Conclusions: Hyposelenemia was prevalent among critically ill patients. Further studies should be conducted to assess the impact of selenium supplementation therapies upon the examined predictors.
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