2014, Number 3
Revista Cubana de Obstetricia y Ginecología 2014; 40 (3)
Molina GO, Méndez RLA, Barrios MA, Viñales PMI
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ABSTRACTPericentric inversions are among the most frequent chromosomal rearrangements with a frequency of 1-2 %. A woman with repeated first trimester pregnancy loss was referred to cytogenetic laboratory of The National Center of Human Genetics. A karyotype conventional banding technique at resolution of ~450 was made. The patient presented an unusual pericentric inversion 46,XX,inv (21)(p11.2 q21.1). The possible gametes as result of crossover events (during the pachytene stage of meiosis I) were discussed. The risk of miscarriages and malformed children were evaluated according the breakpoint in 21 chromosome.