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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2014, Number 4

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Rev Invest Clin 2014; 66 (4)

Carbamazepine produces changes in the auditory pathway of Wistar rats

Alfaro-Rodríguez A, Vargas-Sánchez J, Bandala C, Uribe-Escamilla R

Language: Spanish
References: 35
Page: 345-350
PDF size: 149.07 Kb.


ABSTRACT

Background. Different results have been reported by various authors in studies regarding the impact of the (carbamazepine) CBZ on the auditory evoked responses. Objective. To evaluate the changes in auditory pathway at different sound intensities with CBZ at doses 30 mg/kg, in latencies and interpeak-interval brainstem auditory evoked potentials (BAEPs) in Wistar rats. Material and methods. Twenty adult male Wistar rats (body weight mean, 280-300 g) were used as subjects in this study. BAEPs elicited by stimulus of (30, 50 and 70 dB nHL) intensity and BAEP were obtained with and without CBZ treatment. Results. Peak latencies of BAEPs, between groups were different, in the group with CBZ peak latencies were delaying, but we compared interpeak- intervals between groups and we found significative differences in III-V and I-V at 70 dB nHL intensity. Conclusions. Our results suggest that CBZ modifies BAEPs interpeak- intervals at 70 dB, and latencies since they were delayed. Alterations in the generators of the later waves of BAEPs underlie, AED produced changes in hearing sensitivity with a single no toxic doses. Probably CBZ causes changes in endolymphatic ion composition in the rat inner ear, provoking that latency of BAEPs were delaying, but this requires further studies.


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