Gutiérrez-Zárraga J, Méndez-Gutiérrez E, Rodríguez-Wong U

Language: Spanish
References: 11
Page: 161-165
PDF size: 158.54 Kb.

ABSTRACT

The streptokinases are a grup of proteins in the human extrinsic fibrinolytic system, which need to be activated to give a common factor in the formation of plasminogen, which later will be transformed into plasmin, thus being able to interrupt the cascade of coagulation. His medical application dates back to the early twentieth century in therapeutic trials where it was used to dissolve a pleural effusion. Currently its use is not limited to a medical specialty, since knowing the mechanism of action and dosing allowed competing with other similar drugs. The therapeutic application area ranges from the emergency room, cardiology, ophthalmology, etc.; until his recent passing in the area of coloproctology for treating hemorrhoidal crisis.

REFERENCES

1. Samuel M. Estreptoquinasa. Libro virtual.

2. Tillet WS, Garner RL. The fibrinolyticy acivit of hemolytic streptococci. J Exp Med 1933; 58: 485-502.

3. Tillet WS, Sherry S. The effect in patients of streptococcal desoxyribonuclease on fibrinous, purulent and sanguinouspleural exudations. J Clin Invest 1949; 28: 173-90.

4. Buforn GA, Hidalgo GF, Ortiz LM, Seoane GJ. Fármacos en urgencias. Parte I. Málaga; 2010, p. 35-37.

5. Chibber BAK, Catellino FJ. Regulation of the streptokinasemediated activation of human plasminogen by fribrinogen and chloride ions. J Biol Chem 1986; 261: 5289-95.

6. Bounamezux H. Grupo asesor. Manejo de tromboembolismo. Unidad 3 de actualización Sanofi Hosp. Universitario Cantoral Genova Suecia.

7. Beltrán PI, Álvarez LK, et al. Supositorio que contiene estreptoquinasa recombinante para el tratamiento de la crisis hemorroidal. CIGB. Ed Selfos Scientiae; 2014, p. 12.

8. Mendoza Rodríguez, et al. Estudio comparativo de TNK-Tpa vs. estreptoquinasa. Rev Aso Med Crt 2003; XVII(6): 210-5.

9. Gandorfer A. Pharmacological vitreolysis. Dev Ophthalmol 2007; 39: 149-56.

10. Rizzo S, Pellegrini G, Benocci F, Belting C, Baicchi M. Autologous plasmin for pharmacologic vitreolysis prepared 1 hour before surgery. Retina 2006; 26: 792-6.

11. Diaz-Llopis M, Udaondo P, García-Delpech S, Cervera E, Salom D, Quijada A. Vitrectomía enzimática por inyección intravítrea de plasmina autóloga como tratamiento inicial del edema macular diabético difuso. Arch Soc Esp Oftalmol 2008; 83: 153-9.