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2014, Number S2

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Gac Med Mex 2014; 150 (S2)

Immunohistochemical Expression of CD117 (c-kit) in 75 Renal Cell Tumors

Aguilar-León D, del Ángel-Millán G, Zepeda-Quiroz I, Soria-Céspedes D

Language: Spanish
References: 19
Page: 156-160
PDF size: 243.60 Kb.


ABSTRACT

Objective: c-kit encodes the membrane-bound tyrosine kinase c-kit, whose expression has been identified in several human neoplasms. We analyzed the immunohistochemical expression of c-kit in renal cell tumors. Methods: 75 cases of renal cell tumors were obtained from the surgical pathology archives at the ABC Medical Center in Mexico, for the period 2001 to 2011. We selected one representative paraffin block of the tumor and immunohistochemical staining for CD117 (c-kit) was performed. Immunopositivity was analyzed according cell location, intensity and percentage. Results: c-kit was positive in 20 cases (26.66%), all the oncocytomas and chromophobe renal cell carcinoma were positive. A total of 8.27% of conventional clear cell renal cell carcinomas showed cytoplasmic positivity and one case of papillary renal cell carcinoma was positive. In chromophobe renal cell carcinoma c-kit was positive in the membrane and 44.44% showed combined staining. In oncocytoma four cases showed cytoplasmic positivity, with heterogeneous and less intense staining than chromophobe renal cell carcinoma. Conclusion: c-kit is a useful marker for the diagnosis of chromophobe renal cell carcinoma and oncocytoma vs. other renal cell tumors. Also it is important to define the cell location, intensity, and percentage of neoplastic cells for the differential between chromophobe renal cell carcinoma and oncocytoma.


REFERENCES

  1. Eble JN, Sauter G, Epstein JI, Sesterhenn IA. World Health Organization classification of tumours. Pathology and Genetics, tumors of the urinary system and male genital organs. IARC Press, 2004.

  2. López-Beltran A, Carrasco JC, Cheng L, Scarpelli M, Kirkali Z, Montironi R. 2009 update on the classification of renal epithelial tumors in adults. Int J Urol. 2009;16(5):432-43.

  3. Jain S, Roy S, Amin M, et al. Amylase a-1A (AMY1A) a novel immunohistochemical marker to differentiate chromophobe renal cell carcinoma from benign oncocytoma. Am J Surg Pathol. 2013;37(12):1824-30.

  4. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10-29.

  5. Bodmer D, Van den Hurk W, Van Groningen JJ, et al. Understanding familial and non-familial renal cell cancer. Hum Mol Genet. 2002;11(20):2489-98.

  6. Pavlovich CP, Schimdt LS, Phillips JL. The genetic basis of renal cell carcinoma. Urol Clin North Am. 2003;30(3):437-54.

  7. Motzer RJ, Bander NH, Nanus DM. Renal-cell carcinoma. N Eng J Med. 1996;335(12):865-75.

  8. Yamazaki K, Sakamoto M, Ohta T, Kanai Y, Ohki M, Hirohashi S. Overexpression of KIT in chromophobe renal cell carcinoma. Oncogene. 2003;22(6):847-52.

  9. Linehan WM, Pinto PA, Srinivasan R, et al. Identification of the genes for kidney cancer: opportunity for disease-specific targeted therapeutics. Clin Cancer Res. 2007;13(2 Pt 2):671-9.

  10. Stec R, Grala B, M,aczewski M, Bodnar L, Szczylik C. Chromophobe Renal cell cancer - review of the literature and potential methods of treating metastatic disease. J Exp Clin Cancer Res. 2009;28:134.

  11. Pan CC, Chen PC, Chiang H. Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol. 2004;121(6):878-83.

  12. Argani P, Hicks J, de Marzo AM, et al. Xp11 translocation renal cell carcinoma (RCC): Extended immunohistochemical profile emphasizing novel RCC markers. Am J Surg Pathol. 2010;34(9):1295-303.

  13. Hammerich KH, Ayala GE, Wheeler TM. Application of immunohistochemistry to the genitourinary system (prostate, urinary bladder, testes and kidney). Arch Pathol Lab Med. 2008;132(3):432-40.

  14. Pan CC, Chen PC, Ho DM. The diagnostic utility of MOC31, BerEP4, RCC marker and CD10 in the classification of renal cell carcinoma and renal oncocytoma: an immunohistochemical analysis of 328 cases. Histopathology. 2004;45(5):452-9.

  15. Liang J, Wu YL, Chen BJ, Zhang W, Tanaka Y, Sugiyama H. The C-Kit receptor-mediated signal transduction and tumor-related diseases. Int J Biol Sci. 2013;9(5):435-43.

  16. Lechpammer M, Resnick MB, Sabo E, et al. The diagnostic and prognostic utility of claudin expression in renal cell neoplasms. Mod Pathol. 2008;21(11):1320-9.

  17. Petit A, Castillo M, Santos M, Mellado B, Alcover JB, Mallofré C. KIT expression in chromophobe renal cell carcinoma. Comparative immunohistochemical analysis of KIT expression in different renal cell neoplasms. Am J Surg Pathol. 2004;28(5):676-8.

  18. Huo L, Sugimura J, Tretiakova MS, et al. C-kit expression in renal oncocytomas and chromophobe renal cell carcinomas. Hum Pathol. 2005;36(3):262-8.

  19. Pan CC, Chen PH. A distinct expression pattern and point mutation of c-KIT in papillary renal cell carcinomas. Mod Pathol. 2004;17(11):611-6.




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