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Órgano oficial de la Sociedad Mexicana de Cirugía Dermatológica y Oncológica, AC
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2011, Number 1

Dermatología Cosmética, Médica y Quirúrgica 2011; 9 (1)

Sertaconazole cream 2%. Efficacy and safety in tinea pedis

Bonifaz A, Araiza J, Ramírez DS, Ponce ORM
Full text How to cite this article

Language: Spanish
References: 14
Page: 10-15
PDF size: 611.72 Kb.


Key words:

Tinea pedis, sertaconazole, imidazole, Trichophyton rubrum.

ABSTRACT

Backgroud: Dermatophytoses are keratin tissue infections caused by dermatophytes. Tinea pedis is the most prevalent dermatophytose. Sertaconazole is a wide-spectrum, third generation imidazole, with a good efficacy and safety profile for tineas, pityriasis versicolor and candidiasis.
Objective: to assess the efficacy and safety of sertaconazole in tinea pedis.
Material and methods: 30 patients with clinical and mycologycal diagnosis of tinea pedis were treated with sertaconazole cream 2% topically once daily for 4 weeks, and follow up of 4 weeks.
Results: Two etiologic agents were isolated in this study: Trichophyton rubrum in 93%, and Trichophyton interdigitale in 7%. All patients completed the study: Clinical and mycologycal cure in 86%, improvement in 6.33%, and failure in 6.33%. No side effects were reported.
Conclusion: Sertaconazole is a third generation imidazole considered as a new treatment for tinea pedis, with high efficacy and excellent safety.


REFERENCES

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  2. Degreff H; Heeres J; Borgers M. “Antifungal azoles for skin disorders”. Expert Opin Ther Patents 2006; 16: 1235-1252.

  3. Arenas R, Padilla Desgarennes M, Bonifaz A, López Martínez R, Welsh- Lozano O, et al. Micosis superficiales. Tercera revisión del Consenso Nacional de prevención, diagnóstico y tratamiento. México, AMMM, AC, UNAM. 2005: 3-51.

  4. Bonifaz A. Micología Médica Básica. 3ª ed. México. McGraw-Hill. 2009:

  5. Kircik LH. “Observational evaluation of sertaconazole nitrate cream 2% in the treatment of pruritus related to tinea pedis”. Cutis 2009; 84: 279-283.

  6. Ribotsky BM. “Sertaconazole nitrate cream 2% for the treatment of tinea pedis”. Cutis 2009; 83: 274-277.

  7. Gupta AK, Ryder JE, Chow M, Cooper EA. “Dermatophytosis: The management of fungal infections”. Skinmed 2005; 4: 305-310.

  8. Pfaller MA, Sutton DA. “Review of in vitro activity of sertaconazole nitrate in the treatment of superficial fungal infections”. Diagn Microbiol Infect Dis 2006; 56: 147-152.

  9. Wolff K; Allen-Johnson R. “Fungal Infections of the Skin and Hair”. En: Fitzpatrick´s Dermatology in General Medicine. 6a edición, McGraw Hill, 2009: 221-2217.

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  11. Croxtall JD, Plosker GL. “Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology”. Drugs 2009; 69: 339-59.

  12. Savin R, Jorizzo J. “The safety and efficacy of sertaconazole nitrate cream 2% for tinea pedis”. Cutis 2006; 78: 268-74.

  13. Ghaninejad H, Gholami K, Hashemi P, Hajibabai M, Rahnar Z, et al. “Sertaconazole 2% cream vs Miconazole 2% cream for cutaneous mycoses: a doublé-blind clinical trial”. Clin Exp Dermatol 2009; 34: 837-39.

  14. Alomar C, Bassas S. Casas M. Crespo V, Ferrándiz C, et al. “Multi-centre double blind trial on the efficacy and safety of sertaconazole 2% cream in comparison with miconazole 2% cream on patients suffering from cutaneous mycoses”. Arneimittelforschung 1992; 42: 767-73.




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Dermatología Cosmética, Médica y Quirúrgica. 2011;9