2010, Number 3
Pyoderma gangrenosum: Incidence and associations in Dr. Manuel Gea González General Hospital (1993 to 2009)
De Anda JMC, Karam OM, Gómez VR, Reyes MG, Sáenz CC, Plascencia GA, Vega MME
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Language: Spanish
References: 10
Page: 184-186
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ABSTRACT
Background: Pyoderma gangrenosum is a neutrofilic ulcerative dermatosis associated with systemic diseases in 50 to 70%. The most common association found is with inflammatory bowel disease. There are four common clinical variants: blistering, pustular, granulomatous and vegetans. The histologic findings are nonspecific neutrofilic infiltrates with leucocitoclasia and necrosis. First line treatment consists in corticosteroids, and cyclosporine, associated with immunonodulators in resistant cases.Patients and methods: In a retrospective study from January 1993 to December 2009 we included all patients with clinical and histologic diagnosis of pyoderma gangrenosum.
Results: Out of all 18 patients in 17 years with diagnosis of pyoderma gangrenosum, 9 had no found association with systemic diseases (55.5%); 4, associations with chronic ulcerative colitis (22.2%); 2 with rheumatoid arthritis (11.1%); 2 with leukemia (11.1%) and 1 association with pregnancy (5.55%).
Conclusions: Pyoderma gangrenosum is a rare dermatologic disease. 44.5 % of our patients had some association with a systemic disease and in some cases precedes the diagnosis for years.
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