2014, Number 4
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Rev cubana med 2014; 53 (4)
Fractional excretion of magnesium and status of tubulointerstitium in nephrotic patients
Bacallao MRA, Espinoza SGH, López ML, Mañalich CR, Gutiérrez GF, Roig DIM, Llerena FB
Language: Spanish
References: 25
Page: 363-372
PDF size: 151.17 Kb.
ABSTRACT
Introduction: fractional excretion of electrolytes can be used as an early marker
of renal damage in glomerulopathies.
Objective: to identify the possible relationship between some clinical variables, the
fractional excretion of magnesium and the tubulointerstitial status in patients with
nephrotic proteinuria assisted at The National Institute of Nephrology from April
2012 to June 2013.
Methods: an observational analytical study was conducted. Patients with conditions
that modify the fractional excretion of magnesium were excluded. 40 patients were
included in this study at the Institute of Nephrology from April 2012 until June
2013, and their demographic, anthropometric and clinical data were collected; the
fractional excretion of magnesium was measured as well. Renal biopsies were
practiced to all patients and the percent of fibrosis was measured with the aid of
image J program. Data were processed with Statistical package for Social Science
(SPSS) version 15.0. The statistical technique of frequency distribution analysis was
used; quantitative variables descriptive statistics were calculated. Wilcoxon tests,
Kruskal Wallis and correlation coefficient Spearman's- rho were used in hypothesis
tests.
Results: the percent of interstitial fibrosis was related to fractional excretion of
magnesium (r
sp= 0,37, p= 0,02) and glomerular filtration rate (r
sp= -0,56, p= 0,00). No association of the fractional excretion of magnesium with the use of
drugs or with history of hypertension was found.
Conclusions: tubulointerstitial fibrosis is related to the fractional excretion of
magnesium and glomerular filtration rate in patients with nephrotic proteinuria.
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