Planas HJ, Capote PLL, Herrera AM, González RM, del Cueto IE

Language: Spanish
References: 7
Page: 478-482
PDF size: 128.42 Kb.

ABSTRACT

The dialysis-associated amyloidosis is a frequent complication in patients with end stage renal disease (ESRD) on hemodialysis with over 10 years of treatment. A patient was presented with only four years on hemodialysis had a clinical condition of chronic joint pain, at shoulder, elbow, and knees joints, accompanied by increased volume and loss of function. This patient underwent joint puncture and aspiration of content. Proteinase content with amyloid characteristics, positive Congo red was found. This case is the first of amyloidosis B2 macroglobulin published in a biomedical journal of Cuba. It highlights the possibility that the patient's susceptibility plays an important role in the pathogenesis of this entity.

REFERENCES

1. Gejyo F, Yamada T, Odani S, Nakagawa Y, Arakawa M, Kunitomo T, et al. A new form of amyloid protein associated with chronic hemodialysis was identified as b2- microglobulin. Biochem Biophys Res Commun. 1985;129:701-6.

2. Pengyao Z, Xiaoying F, Sawashita J, Junjie Y, Beiru Z, Higuchi K, et al. Mouse model to study human A b2M amyloidosis: generation of a transgenic mouse with excessive expression of human b2-microglobulin. Amyloid. 2010;17(2):50-62.

3. Bellotti V, Chiti F. Amyloidogenesis in its biological environment: challenging a fundamental issue in protein misfolding diseases. Curr Opin Struct Biol. 2008;18:771-9.

4. Heegaard N. β2-microglobulin: from physiology to amyloidosis. Amyloid. 2009;16(3):151-73.

5. Floege J, Ketteler M. beta2-microglobulin-derived amyloidosis: an update. Kidney Int. Supplement 2001;78:S164-171.

6. Shyue-Luen C, Ping-Chin L, Chien-Jui C, Li-Cheng Y, Hong-Shang H. Bullous amyloidosis in a hemodialysis patient is myeloma-associated rather than hemodialysis-associated amyloidosis. Amyloid. 2007;14(2):153-6.

7. Floege J, Schaffer J, Koch KM. Scintigraphic methods to detect B2-microglobulin associated amiloidosis (AB2- microglobulin amiloidosis. Nephrol Dial Transplant. 2001;16(Suppl 4):12-16.