Domínguez LLMO, Aldama CA, Rivelli V, Mendoza G

Language: Spanish
References: 13
Page: 195-198
PDF size: 358.33 Kb.

ABSTRACT

Background: Granuloma Annulare (GA) is a chronic inflammatory cutaneous disease of unknown etiology. Usually self limited and with different clinical forms. The objective of this paper is to determine the demographic and clinical characteristics as well as its morbidity .
Material and Method: This is an open, descriptive and retrospective study of patients with clinical diagnosis of Granuloma Annulare at the Dermatology Department of the National Hospital in Paraguay from 2000 to 2007
Results: We studied 17 patients with clinical diagnosis of Granuloma Annulare; it represents 0.39 % of patients from this service; In 12 of them diagnosis was confirmed by histopathology. The mean age was 38.2, and the average relation female:male 7:1. The most frequent clinical form was the classical localized (8 cases), followed by the disseminated form (5 cases) and only one case of macular, subcutaneous and perforating forms. The most commonly affected site was the dorsal aspect of hands and feet. In one case the lips’ Mucosae was involved. We also observed hyperglicemic levels (4 cases): 3 with diabetes Mellitus type 2 or 1 with altered fastening glucose levels. The diabetic patients: 2 cases with disseminated GA and one with the classical localized form.
Treatment with topical corticosteroids had good and poor responses.
Conclusions: Granuloma Annulare is an uncommon condition with different clinical forms. The most frequent was the localizad form in women and some cases with glycemic alterations.

REFERENCES

1. Dahl MV. “Granuloma anular”, en Fitztpatrik TB, Eisen AZ, Wolff K. Freedberg I, Austen KF. Dermatologia en Medicina General. 4a ed. New York: McGraw-Hill, 1998: 1245-1249.

2. López Esteberanz J L. “Enfermedades granulomatosas de causa desconocida”, en Iglesias Diez L, Guerra Tapia A; Ortiz Romero PL. Tratado de Dermatología. 2a ed España: Mc Graw-Hill-Interame ri - cana, 2004: 583-584.

3. Shapiro P E. “Granulomas no infecciosos”, en Elder D, Elenitsas R, Jaworsky C, Johnson B Lever. Histopatología de la piel. 8a ed. Buenos Aires: Intermédica; 1999: 289-308.

4. Narvaez V, Vega M E, Saez de Ocariz M, Castillo M, Domínguez L. Granuloma Anular en pacientes pediatricos. Dermatol Pediatr Lat. 2005; 3(2): 117-122

5. Garcia Font M, Curcó Botarguez N, Pagerols Bonilla X. Granuloma Anu - lar Maculoso Siete Nuevos Casos. Med Cutan I L A. 2004; 32(1): 23-26.

6. Jaimovich L. Tratamiento del Granuloma Anular. Med Cutan I L A 1992; 20: 133-136.

7. Ibarra Duran G, Mena Cedilla C A, Arroyo Pineda A I. Tratamiento del Granuloma Anular con inyecciòn subcutanea de agua bidestilada en niños. Dermatología Rev Mex. 1995; 39(4): 206-209.

8. Guiote Domínguez M V, Vilanova Mateu A, Vieira R, Hernandez J, Naranjo Suites R,Gutierrez Salmerón M T. Granuloma Anular Generalizado: respuesta al tratamiento con vitamina E. Med Cut I L A. 2005; 33(6): 261-263.

9. Guerrero Fernandez J, Guiote Domínguez M V, Guerrero Vazquez J, Ruso de la Torre F. Granuloma Anular Diseminado a proposito de 2 casos. An Esp Pedíat. 2001; 55: 178-180.

10. Lucky A W, Neds S, Pros, Bove K, Nain L, Joseph L. Papular Umbilicated Granuloma Annulare. A report Four Pediatric Cases. Arch Dermat. 1992, 128: 1375-1378.

11. Donathz L B, Pagano P, Allevato M A, Granuloma Anular Generalizado. Act Terap Dermatol. 1996; 19: 9-17.

12. Honeyman J, Granuloma Anular y Diabetes. Rev Chil Dermatol. 2005; 21(1): 60-65.

13. Martinez del Sel J, Minando M, Viloldo V, Casas G, Allevato M A, Cabrera H N. Granuloma Anular Generalizado variedad papular. Arch Arg Dermatol. 2005; 55(6): 259-261.