medigraphic.com
ISSN 1028-4796 (Print)

2014, Number 3

<< Back Next >>

Rev Cubana Plant Med 2014; 19 (3)

Preclinical validation of the peripheral and central analgesic activity of decoction of fresh leaves of Persea americana Mill. (avocado) and Musa x paradisiaca L. (banana)

García HAI, López BM, Morejón RZ, Boucourt RE, Victoria AMC, Martínez HI, Acosta LLL, Doménigo GA, Brito AG, Morón RFJ

Language: Spanish
References: 22
Page: 225-234
PDF size: 220.18 Kb.


ABSTRACT

Introduction: Persea americana Mill.(avocado) and Musa x paradisiaca L. (banana) are medicinal plants with traditional uses in folk medicine. Reports refer to the beneficial effects of a decoction of fresh leaves of avocado in the treatment of urinary infection, coughing and bronchitis. Decoction of banana fresh leaves is used to treat the flu, coughing and inflammation. This has been documented by TRAMIL surveys. The preclinical information found in the databases SciELO, CUMED, LIS CUBA and MEDLINE was not sufficient to validate the uses listed above.
Objectives: evaluate the preclinical peripheral and central analgesic activity of a 30 % decoction of fresh leaves of Persea americana Mill. (avocado) and Musa x paradisiaca L. (banana).
Methods: fresh leaves of P. americana and M. paradisiaca were collected and 30 % decoctions were prepared. Peripheral analgesic activity was evaluated with the acetic acid induced writhing model (writhing test), whereas central analgesic activity was assessed with the tail flick model in mice by immersion in 55 °C water. The doses used were 1, 5 and 10 grams of plant material/kg of body weight.
Results: decoctions of fresh leaves of P. americana and M. paradisiaca at the study doses significantly inhibited the painful response induced by acetic acid with p=6.909e-08 and p=2.842e-03, respectively. In the tail flick evaluation the decoction of fresh leaves of P. americana had a significant non-dose dependent response at 5g/kg with p=7.018e-03. A significant response was not obtained from the other doses studied or from the M. paradisiaca decoction.
Conclusions: results permit the preclinical validation of the peripheral analgesic activity of the decoction of fresh leaves of P. americana (avocado) and M. paradisiaca (banana), as well as the central analgesic activity of P. americana, validating the traditional use of both plants.


REFERENCES

  1. TRAMIL. Farmacopea Vegetal Caribeña. 2da Ed. [CD-ROM]. León, Nicaragua: Editorial Universitaria UNAN-León; 2005 p. 486.

  2. Missouri Botanical Garden – w3TROPICOS. Persea americana Mill. Nomenclatural Data Base. [en línea]. [citado 20 Jul. 2014]. Disponible en: http://www.tropicos.org/Name/17801262

  3. Roig JT. Plantas Medicinales, Aromáticas y Venenosas de Cuba. 2da ed. La Habana: Editorial Científico-Técnica;1992 p.109-11.

  4. TRAMIL. Persea americana Mill. Nomenclatural Data Base [en línea]. [citado 20 Jul. 2014]. Disponible en: http://www.tramil.net/fototeca/imageDisplay.php?id_elem=272

  5. Missouri Botanical Garden – w3TROPICOS. Musa x paradisiaca L. Nomenclatural Data Base. [en línea]. [citado 20 Jul. 2014]. Disponible en: http://www.tropicos.org/Name/21500456

  6. Roig JT. Plantas Medicinales, Aromáticas y Venenosas de Cuba. 2da ed. La Habana: Editorial Científico-Técnica;1992 p.768-69.

  7. TRAMIL. Musa x paradisiaca L. Nomenclatural Data Base [en línea]. [citado 20 Jul. 2014]. Disponible en: http://www.tramil.net/fototeca/imageDisplay.php?id_elem=238

  8. Cuba. Para la Protección de la Salud Pública. Principios de las Buenas Prácticas de Laboratorio no Clínico de Seguridad Sanitaria y Medioambiental: Regulación 39/2004. La Habana: El Buró Regulatorio; 2004.

  9. EE.UU. National Research Council. Guide for the Care and Use of Laboratory Animals. Washington DC: National Academy Press; 2001.p.21-79.

  10. Lapa AJ, Monteiro de Lima TC. Métodos farmacológicos para el estudio de la actividad analgésica/antiinflamatoria. En: Lapa AJ, Souccar C, Lima-Landman MTR. Métodos de Evaluación de la Actividad Farmacológica de Plantas Medicinales. Sao Paulo: CYTED/CNPq; 2002. p. 60-71

  11. Cerveró F. Neurobiología del dolor. Rev Neurol. 2006;30(6):551-555.

  12. Mwonjoria JK, Kariuki HN, Waweru FN. The antinociceptive antipyretic effects of Solanum incanum (Linnaeus) in animal models. International Journal of Phytopharmacology. 2011;2(1):22-6.

  13. Burke A, Smyth E, Fitzgerald GA. Analgesic-antipyretic agents; pharmacotherapy of gout. In: Goodman & Gilman's. The Pharmacological Basis of Therapeutics,11th Ed; [CD-ROM]. New York: McGraw-Hill Medical Publishing Division; 2006.

  14. Sánchez N, Bu Wong M, Pérez-Saad H, Lara Gl, Scull I. Efecto del zumo de Morinda citrifolia L. (noni) en modelos de analgesia. Rev Cubana Plant Med. [revista en la Internet]. 2012 Sep [citado 2014 Jul 30];17(3):213-16. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028- 47962012000300002&lng=es .

  15. Vicente R, Matos R, Corsino J, Tabajara de Oliveira D. Antiinflammatory, antinociceptive and antipyretic effects of hydroethanolic extract from Macrosiphonia velame (A. St.-Hil.) M. Arg. in animal models. Braz. J. Pharm. Sci. [serial on the Internet]. 2010 Sep [cited 2014 July 24]; 46(3):515-23. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984- 82502010000300015&lng =en. http://dx.doi.org/10.1590/S1984- 82502010000300015 .

  16. Atsang KG, Dzeufiet PD, Foyet S, Dimo T and Kamtchouing P. Analgesic and Anti-inflammatory Effect of the Aqueous Extract of Dichrostachys glomerata (Forssk.) Hutch Fruits. European Journal of Medicinal Plants. [serial on the Internet]. 2014 May [cited 2014 July 24]; 4(8):964-78. Available from: http://www.sciencedomain.org/abstract.php?iid=519&id=13&aid=4759

  17. Bashar K, Ibrahim M, Sultana I, Hossain I, Tasneem Z, Kuddus R, et al. Preliminary Phytochemical Screenings and Antipyretic, Analgesic and Antiinflammatory Activities of Methanol Extract of Vernonia cinerea Less. European Journal of Medicinal Plants. [serial on the Internet]. 2014 Jun [cited 2014 July 24]; 4(10):0-0 Available from: http://www.sciencedomain.org/abstract.php?iid=575&id=13&aid=5092#. U9p5Fz_Mu00

  18. Esther O, Oluwole A, Ajidahun A. Analgesic, anti-inflammatory and antipyretic effects of dried root ethanolic extract of Strophanthus sarmentosus p. DC (Apocynaceae). International Research Journal of Pharmacy and Pharmacology. 2011;1(4):62-9.

  19. Morón F, Victoria MC, Morejón Z, López M, García AI, Fuentes V, et al. Tamizaje fitoquímico, actividad analgésica y antiinflamatoria de decocción de Costus pictus D. Don. Rev Cubana Plant Med. 2008;13(4). Disponible en: http://bvs.sld.cu/revistas/pla/vol13_4_08/pla13408.htm

  20. Regina E, Diedrich D, Bolzan C, Giacomelli SR. Toxicological and pharmacological evaluation of Discaria americana Gillies & Hook (Rhamnaceae) in mice. Braz. J. Pharm. Sci. [serial on the Internet]. 2012 June [cited 2014 July 24]; 48(2):273-280. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984- 82502012000200011&lng =en. http://dx.doi.org/10.1590/S1984- 82502012000200011

  21. Gemosén-Robineau L, Delens M, García-González M, Herrera J, Morón F, Sáenz- Campos D, Solís P, editores. Matricaria recutita L. Farmacopea Vegetal Caribeña 2da ed. [CD-ROM]. León (Nicaragua): Editorial Universitaria UNAN-León; 2005. p. 280-5.

  22. Vanaclocha B, Cañigueral S, Vila R, Risco E, Pérez F, Portillo A, et al. Ulmaria. Monografías de Plantas Medicinales. En: Vanaclocha B, Cañigueral S, editores. Fitoterapia. Vademécum de Prescripción. 4ª ed. Barcelona: MASSON, S.A.; 2003. p. 487-8.




2020     |     www.medigraphic.com