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ISSN 2520-9078 (Electronic)

2014, Number 2

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Revista de Ciencias Médicas de la Habana 2014; 20 (2)

Vascular dementia as a risk marker in elderly hypertensive patients

Canciano CE, Silva VN, León LE, Valdés BS

Language: Spanish
References: 13
Page: 135-141
PDF size: 151.38 Kb.


ABSTRACT

Introduction: the relationship between arterial hypertension and vascular dementia is increasingly discussed.
Objectives: to determine differences between hypertensive patients over 60 years old with vascular dementia in nondemented hypertensives.
Methods: a case-control study was conducted in the period from January 2011 to January 2013, at “Felipe I Rodríguez Ramos” University Polyclinic, in the municipality of San Antonio de los Baños, Artemisa province, it was randomly selected 200 hypertensives over 60 years old divided into 2 groups of 100 patients: Group A with vascular dementia and group B non-demented, particularizing: age, time to progression of arterial hypertension and its control, most-used pharmacological group, depending on the dose, complications of target organs.
Results: the oldest populations belonged to Group A (x 85.5 years) with deviation to the right, according to Fisher test (1.8). Only 35 % of the demented patients had uncontrolled hypertension, 34.2 % of them being hypertensive for over 10 years with proven association between variables according to Spearman test. 34 % of patients in Group A used angiotensin-converting-enzyme inhibitor at high doses, this was the most frequently used pharmacological group in general (93 %). Cardiac complications predominated in demented (OR 2.8).
Conclusions: the occurrence of vascular dementia in hypertensives unfavorably marks its progression and prognosis, depending on multiple variables difficult to control.


REFERENCES

  1. Duara R, Barker W, López Alberola R, Loewenstein DA. Alzheimer´s disease: interaction of apolipoprotein E genotype, family history of dementia, education, ethnicity and age onset. Neurology [Internet]. 2010 [citado 20 Ene 2012];46(6). Disponible en: http://www.researchgate.net/publication/14550115_Alzheimer's_disease_interacti on_of_apolipoprotein_E_genotype_family_history_of_dementia_gender_educatio n_ethnicity_and_age_of_onset

  2. Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson LA, Nilsson L, et al. 15- year longitudinal study of blood pressure and dementia. Lancet [Internet]. 1996 [citado 20 Ene 2012];347. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/8609748

  3. Gascon-Bayarri J, Rene R, Del Barrio JL, De Pedro-Cuesta J, Ramon JM, Manubens JM, et al. Prevalence of dementia subtypes in El Prat de Llobregat, Catalonia, Spain: the PRATICON study. Neuroepidemiology 2007;28:224-34.

  4. Jellinger KA, Attems J. Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease. Acta Neuropathol [Internet]. 2008 Apr [citado 20 Ene 2012]; 115(4). Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/18273624

  5. Klein JC, Eggers C, Kalbe E, Weisenbach S, Hohmann S, Vollmar S, et al. Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo. Neurology [Internet]. 2010 [citado 20 Jul 2012];74(11). Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/20181924

  6. Iranzo A, Molinuevo JL, Santamaria J, Serradell M, Marti MJ, Valdeorriola F, et al. Rapid-eye-movement sleep behaviour disorder as an early market for a neurodegenerative disorder: a descriptive study. Lancet Neurol [Internet]. 2009[citado 20 Jul 2012];5(7). Disponible en. http://www.ncbi.nlm.nih.gov/pubmed/16781987

  7. Llibre Rodríguez JJ, Fernández Y, Marcheco B, Contreras N, López AM, Otero M, et al. Prevalence of dementia and Alzheimer's disease in a Havana Municipality: a community-based study among elderly residents. MEDICC Rev [Internet]. 2009 Apr [citado 20 Jul 2012];11(2). Disponible en: http://www.medicc.org/mediccreview/pdf.php?lang=&id=92

  8. Comisión Nacional Técnica Asesora del Programa de Hipertensión Arterial del MINSAP. Guía cubana para la prevención, diagnóstico y tratamiento de la hipertensión arterial [Internet]. La Habana: Ministerio de Salúd Pública; 2006 [citado 06 Ago 2012]. Disponible en. http://www.sld.cu/galerias/pdf/servicios/hta/guia_hta_cubana__version_final_200 7revisada_impresa.pdf

  9. Shiau MY, Yu L, Yuan HS, Lin JH, Liu CK. Functional performance of Alzheimer’s disease and vascular dementia in Southern Taiwan. Kaohsiung J Med Sci [Internet]. 2006 Sept [citado 06 Ago 2012];22(9). Disponible en: http://pt.kmu.edu.tw/ezcatfiles/b035/img/img/3/KJMS2006-437.pdf

  10. Groves WC, Brandt J, Steinberg M,Warren A, Rosenblatt A, Baker A, et al. Vascular dementia and Alzheimer disease: is there a difference? A comparison of symptoms by disease duration. J Neuropsychiatry Clin Neurosci [Internet]. 2000 [citado 06 Ago 2012];12(3). Disponible en: http://neuro.psychiatryonline.org/article.aspx?articleID=100891

  11. Prince MJ, Bird AS, Blizard RA, Mann AH. Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's treatment trial of hypertension in older adults. BMJ [internet]. 1996 [citado 28 Nov 2012];312. Disponible en: http://www.bmj.com/content/312/7034/801

  12. Kavirajan H, Schneider LS. Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials. Lancet Neurol [Internet]. 2007 [citado 28 Nov 2012];6(9). Disponible en: http://www.sciencedirect.com/science/article/pii/S1474442207701953

  13. Llibre-Rodríguez JJ. Guerra-Hernández H. Pérez-Cruz H. Bayarre-Vea S. Fernández-Ramírez M. González-Rodríguez JA, et al. Síndrome demencial y factores de riesgo en adultos mayores de 60 años residentes en la Habana. Rev Neurol [Internet]. 1999 [citado 28 Nov 2012];29(10). Disponible en: http://www.revneurol.com/sec/resumen.php?id=99312




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