medigraphic.com
ISSN 1561-3011 (Electronic)

2014, Number 2

<< Back Next >>

Rev Cubana Invest Bioméd 2014; 33 (2)

Reibergram to evaluate the Mannan binding Lectin intrathecal synthesis

Padilla-Docal B, Ramírez APJ, Reiber H, Jensenius JC, Dorta-Contreras AJ

Language: Spanish
References: 20
Page: 168-176
PDF size: 112.54 Kb.


ABSTRACT

Background: the dynamics of brain derived proteins in cerebrospinal fluid is different from the dynamics of blood-derived proteins. Aim: To describe the empirical data for mannan binding lectin and gives a theoretical interpretation of the dynamics of this protein in cerebrospinal fluid through a new reibergram.
Methods: serum and cerebrospinal fluid mannan binding lectin were measured in 40 normal adults by immunofluorometric assays. The diagnostic criteria were based in; normal control samples defined clinically and diseases with blood-cerebrospinal fluid barrier dysfunction.
Results: correlation coefficient between cerebrospinal fluid MBL and serum MBL was very low. Mannan binding lectin reibergram was designed according with previous procedures.
Conclusion: under all conditions of the blood-cerebrospinal fluid barrier, the reibergram can identify the occurrence of intrathecal mannan binding lectin synthesis.


REFERENCES

  1. Reiber H. Dynamics of brain-derived proteins in cerebrospinal fluid. Clin Chim Acta 2001;310:173-86.

  2. Selander B, Martensson U, Weintraub A, Holmström E, Matsushita M, Thiel S, Jensenius JC,Truedsson, Anders G. Sjöholm A. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2. J Clin Invest 2006;116:1425-34.

  3. Lanzrein AS, Thiel T, Jensenius JC, Sim RB, Hugh PV, Sim E. Mannan-binding lectin in human serum, cerebrospinal fluid and brain tissue and its role in Alzheimer´s disease. NeuroReport 1998;9:1491-5.

  4. Reiber H. Flow rate of cerebrospinal fluid CSF-a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci 1994;122:189-203.

  5. Reiber H. CSF flows-its influence on CSF concentration of brain-derived and blood-derived proteins. In: Teelken A, Korf J, editors. Neurochemistry. New York: Plenum 1997:51-72.

  6. Steffen T, Møller-Kristensen M, Lisbeth J, Jenseniues JC. Assays for the functional activity of the mannan-binding lectin pathway of complement activation. Immunobiol 2002;205:446-54.

  7. Reiber H. The hyperbolic function: a mathematical solution of the protein flux/CSF flow model for blood CSF barrier function. J Neurol Sci 1994;126:243-45.

  8. Padilla-Docal B, Dorta-Contreras AJ, Bu-Coifiu-Fanego R, Rodríguez-Rey A, Gutiérrez-Hernández JC, de Paula-Almeida OS. Reibergram of intrathecal synthesis of C4 in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. Am J Trop Med Hyg 2010;82:1094-98.

  9. Dorta-Contreras AJ, Noris-García E, Padilla-Docal B, Rodríguez-Rey A, Magraner-Tarrau ME, Bu Coifiú-Fanego R. Reibergrama para la evaluación de la síntesis intratecal de C3c. Arq Neuropsiquiatr 2006;64(3-A):585-88.

  10. Padilla-Docal B, Dorta Contreras AJ, Bu Coifiu-Fanego R, Barroso Callol J,Hernández-Fundora H. Intrathecal synthesis of IgE in children with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis. Fluids Barriers CNS [Internet]. 2008, [cited 2008 Sep 14];5:18 [about 5 p.]. Available from: http://www.cerebrospinalfluidresearch.com/content/5/1/18

  11. Abood S. Quality improvement initiative in nursing homes: the ANA acts in an advisory role. Am J Nurs [Internet]. 2002 Jun [cited 2002 Aug 12]; 102(6): [about 1 p.]. Available from: http://www.nursingworld.org/AJN/2002/june/Wawatch.htmArticle.

  12. Dorta-Conteras AJ, Noris-García E, Escobar-Pérez X, Padilla-Docal B. IgG1, IgG2 and IgE intrathecal synthesis in Angiostrongylus cantonensis meningoencephalitis. J Neurol Sci 2005;238:65-70.

  13. Kawasaki T, Etoh R, Yamashina I. Isolation and characterization of a mannan-binding protein from rabbit liver. Biochem Biophys Res Commun 1978;81:1018-24.

  14. Eddie Ip WK, Takahashi K, Ezekowitz Alan R, Stuart Lynda M. Mannose-binding lectin and innate immunity. Immunol Rev 2009;230:9-21.

  15. Foley J, Mullighan CG, McGrath DS, Pantelidis P, Marshalf S, Lympany PA, Welsh KI, du Bois RM. Mannose-binding lectin promoter and structural gene variants in sarcoidosis. Eur J Clin lnvest 2000;30:549-52.

  16. Reiber H. Proteins in cerebrospinal fluid and blood: Barriers, CSF flow rate and source-related dynamics. Rest Neurol Neurosc 2003;21:79-96.

  17. Dorta Contreras AJ, Reiber H. Teoría de la difusión molecular/ flujo del líquido cefalorraquídeo. Rev Neurol 2004, 39:564-69.

  18. Zoran Redzic. Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences. Fluids Barriers CNS [Internet]. 2011, [cited 2011 Feb 10]; 8:3: [about 10 p.] Available from: http://www.fluidsbarrierscns.com/content/8/1/3

  19. Kuraya M, Matsushita M, Endo Y, Thiel S, Fujita T. Expression of H-ficolin/Hakata antigen, manosse-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G. Internat Immunol 2003;15:109-17.

  20. Dorta Contreras AJ. Reibergramas: elemento esencial en el análisis inmunológico del líquido cefalorraquídeo. Rev Neurol 1999;28:996-8.




2020     |     www.medigraphic.com