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2006, Number 1

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Dermatología Cosmética, Médica y Quirúrgica 2006; 4 (1)

Severe and fatal cases of adverse drug reactions. About 53 cases

Aldama CAB, Gorostiaga G, Rivelli V, Mendoza G

Language: Spanish
References: 13
Page: 22-26
PDF size: 237.13 Kb.


ABSTRACT

Background: Adverse drug reactions are frequent dermatological conditions, with a wide clinical spectrum from mild to severe and potentially lethal cases. Our aim was to determine the frequency of the severe and lethal cases, their clinical pictures and to identify causal drugs and related factors.
Material and methods: This is a retrospective 10 years report (1993–2003) of the cases at the Dermatology Department at the National Hospital in Paraguay, South America.
Results: 231 cases of adverse drug reactions were studied. 53 were severe cases (22.9%) and 5 of them with a lethal outcome. The most common clinical features were erythrodermia, Stevens-Johnson’s syndrome, toxic epidermal necrolysis and hypersensitivity syndrome. The most commonly involved drugs were carbamazepine, phenytoine, dipirone and diclofenac.
Conclusions: The severe and lethal cases represented almost a quarter of the adverse drug reactions and they were related to their clinical features, the involved drug and the age of the patient.


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