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ISSN 2007-3194 (Print)
Órgano de difusión oficial del Instituto Materno Infantil del Estado de México

2014, Number 2

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Arch Inv Mat Inf 2014; 6 (2)

Neutropenia cíclica: presentación de un caso en un lactante menor

Gómez CDE, Guajardo BTV, Rodríguez BR, Rodríguez BI

Language: Spanish
References: 6
Page: 64-66
PDF size: 76.06 Kb.


ABSTRACT

Cyclical neutropenia is an infrequent congenital hereditary disease characterized by periods of neutropenia that can be moderate to severe that resolve spontaneously. The periods may vary between 21 to 28 days and are caused by a disorder in the ELA2 protein, which is a neutrophil elastase, inducing a failure in granulopoiesis. The clinical manifestations of this disease are highly diverse, as it may develop as an asymptomatic patient or as a severe sepsis. We present a clinical case of a three-month- old male patient in whom we found severe neutropenia within the first days of life. Within his three months of life, he has had three different hospitalizations, in which he has presented severe neutropenia, with approximately 21 to 28 days between each hospitalization. We made complementary studies in each hospitalization and found a clinical presentation compatible with cyclic neutropenia.


REFERENCES

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  2. Iglesias BC, Mata ZD, Ledezma BI, Martínez BJP, Marugán de Miguelsanz JM, Neutropenia cíclica: tratamiento con factor estimulante de colonias de granulocitos recombinante en un caso de novo, An Pediatr, 2009; 70 (4): 403-405.

  3. Pulley BIE, Ortiz LF. Neutropenia crónica en la infancia, VITAE,2007; 31. Disponible en: http://vitae.ucv.ve/pdfs/VITAE_824.pdf

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