2015, Number 03
Ginecol Obstet Mex 2015; 83 (03)
Assessment of progesterone levels on the day of the hCG administration as a predictor of success of antagonist stimulation protocols for IVF
Kably-Ambe A, Roque-Sánchez AM, Soriano-Ortega KP, Carballo-Mondragón E, Durán-Monterrosas L
Language: Spanish
References: 10
Page: 155-161
PDF size: 410.82 Kb.
ABSTRACT
Background: There are reports of deleterious effect when progesterone
concentration is high during the follicular phase in cycles of in vitro
fertilization. In our environment has not carried out a study to evaluate
the pregnancy rate compared with progesterone concentration on the
day of application of hCG.
Objective: To evaluate the pregnancy rate and outcome of in vitro fertilization
cycle according to serum progesterone concentration on the
day of application of hCG.
Material and methods: A retrospective, observational, cross-sectional
study of 486 cycles of
in vitro fertilization was done in the Centro
Mexicano de Fertilidad of CEPAM (Hospital Angeles de las Lomas) from
January 2009 to February 2014. We included all cases where it was used
a stimulation protocol GnRH antagonist flexible scheme.
Results: When levels of progesterone are high, those of estradiol are
also high and the number of retrieved oocytes and oocyte quality
are lower. There was no difference in the percentage of fertilization,
but at higher concentration of progesterone lower percentage of
embryonic segmentation. Difference was recorded in the pregnancy
rate only when progesterone concentration on the day of hCG application
was › 4 ng/mL.
Conclusion: Pregnancy rate decreases when the concentration of progesterone
on the day of hCG application is ≥ 4 ng/mL.
REFERENCES
Lee VC, Li RH, Chai J, Yeung TW, et al. Effect of preovulatory progesterone elevation and duration of progesterone elevation on the pregnancy rate of frozen-thawed embryo transfer in natural cycles. Fertil Steril 2014 May;101:1288-93.
Venetis CA, Kolibianakis EM, Papanikolaou E, Bontis J, et al. Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis. Hum Reprod Update 2007;13:343-55.
Fleming R, Jenkins J. The source and implications of progesterone rise during the follicular phase of assisted reproduction cycle. Reprod Biomed Online 2010;21(4):446- 9.
Smitz J, Andersen AN, Devroey P, Arce JC, MERIT Group. Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients. Hum Reprod 2007;22:676-87.
Li R, Qiao J, Wang L, Zhen X, Lu Y. Serum progesterone concentration on day of HCG administration and IVF outcome. Reprod Biomed Online 2008;16:627-31.
Melo M, Meseguer M, Garrido N, Bosch E, et al. The significance of premature luteinization in an oocyte-donation programme. Hum Reprod 2006;21:1503-7.
Papanikolaou EG, Kolibianakis EM, Pozzobon C, Tank P, et al. Progesterone rise on the day of human chorionic gonadotropin administration impairs pregnancy outcome in day 3 single-embryo transfer, while has no effect on day 5 single blastocyst transfer. Fertil Steril 2009;91:949-52.
Macklon NS, Stouffer RL, Giudice LC, Fauser BCJM. The Science behind 25 years of Ovarian Stimulation for In Vitro Fertilization. Endocr Rev 2006;27(2):170-207.
Van Vaerenbergh I, Fatemi H, Blockeel C, Van Lommel L, et al. Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression. Reprod Biomed Online 2011;22:263-71.
Huang CC, Lien YR, Chen HF, Chen MJ, et al. The duration of pre- ovulatory serum progesterone elevation before hCG administration affects the outcome of IVF/ICSI cycles. Hum Reprod 2012;27:2036-45.
Full text