2015, Number 03
Ginecol Obstet Mex 2015; 83 (03)
Assessment of progesterone levels on the day of the hCG administration as a predictor of success of antagonist stimulation protocols for IVF
Kably-Ambe A, Roque-Sánchez AM, Soriano-Ortega KP, Carballo-Mondragón E, Durán-Monterrosas L
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ABSTRACTBackground: There are reports of deleterious effect when progesterone concentration is high during the follicular phase in cycles of in vitro fertilization. In our environment has not carried out a study to evaluate the pregnancy rate compared with progesterone concentration on the day of application of hCG.
Objective: To evaluate the pregnancy rate and outcome of in vitro fertilization cycle according to serum progesterone concentration on the day of application of hCG.
Material and methods: A retrospective, observational, cross-sectional study of 486 cycles of in vitro fertilization was done in the Centro Mexicano de Fertilidad of CEPAM (Hospital Angeles de las Lomas) from January 2009 to February 2014. We included all cases where it was used a stimulation protocol GnRH antagonist flexible scheme.
Results: When levels of progesterone are high, those of estradiol are also high and the number of retrieved oocytes and oocyte quality are lower. There was no difference in the percentage of fertilization, but at higher concentration of progesterone lower percentage of embryonic segmentation. Difference was recorded in the pregnancy rate only when progesterone concentration on the day of hCG application was › 4 ng/mL.
Conclusion: Pregnancy rate decreases when the concentration of progesterone on the day of hCG application is ≥ 4 ng/mL.