medigraphic.com
ISSN 1561-3062 (Electronic)

2012, Number 1

<< Back Next >>

Revista Cubana de Obstetricia y Ginecología 2012; 38 (1)

Toxoplasmosis and pregnancy

Sánchez LR, Couret CMP, Ginorio GD, Nodarse RA, Sánchez RN, Soler GI, Ortúzar CA, Sanabria AAM, Peña ARA

Language: Spanish
References: 15
Page: 99-106
PDF size: 149.00 Kb.


ABSTRACT

Introduction: The toxoplasmosis is a zoonosis involving a third of world population. It is associated with congenital infections and abortion.
Objective: To describe a clinical case of a patient presenting with toxoplasmosis associated with pregnancy.
Methods: Patient aged 36 who at 21 weeks of pregnancy is assessed by the Provincial Genetics Department of La Habana by determination of IgM for positive toxoplasmosis. IgG and IgM determinations were performed and polymerase chain reaction (PCR) in amniotic fluid for Toxoplasm, which was positive. The couple received genetic advice and started a specific treatment. At 32 weeks is admitted in our service diagnosed with preterm delivery threat. A cesarean section of corporeal segment was carried out as well as surgical sterilization with a diagnosis of acute fetal suffering.
Results: The conception was a male newborn weighing 1 800 g, a 9/9 Apgar scale. The newborn receive treatment with sulfadiazine, pirimetamine and folinic acid. Later, IgE and IgM determinations were made being negatives. She is discharged at 42 days weighing 2 520 g, a favorable evolution and ophthalmic assessment. Serologic follow-up of newborn was prescribed.
Conclusions: Transmission rate in the seroconversion increases by week of gestational age, thus it is necessary to start an early therapy to avoid the complications and to carry out the long-term follow-up of these newborns to assess the disease prognosis.


REFERENCES

  1. Ocampo Lina M, Duarte-Gandica I. A model of congenital toxoplasmosis transmission dynamics. Rev Salud Pública [serial on the Internet]. 2010;12(2). Disponible en: http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0124 - 00642010000200015&lng=en

  2. Weiss L DJ. Toxoplasmosis: a history of clinical observations. Int J Parasitol. 2009 July 1;39(8):895-901.

  3. Kravetz J. Congenital toxoplasmosis. Yale University School of Medicine. Yale University, West Haven, USA. Published online 2008 March 27. PubMed Central. 2008 Disponible en: http://linkinghub.elsevier.com/retrieve/pii/S0929- 693X(11)00183-7

  4. Sosa Díaz R, Sosa Díaz J, Jordán M, González G. Toxoplasmosis Congénita. Aspectos a tener en cuenta. Facultad de Ciencias Médicas "Juan Guiteras Gener". Matanzas. Revista Médica Electrónica 2006;28(3). Disponible en: http://www.revmatanzas.sld.cu/revista%20medica/ano%202006/vol3%202006/te ma12.htm

  5. Montoya JG, Remington JS. Management of Toxoplasma gondii infection during pregnancy.Clin Infect Dis. 2008 Aug 15;47(4):554-66. Disponible en: http://cid.oxfordjournals.org/content/47/4/554.long

  6. Valdés V, Legagneur H, Watrin V, Paris L, Hascoët JM. Congenital toxoplasmosis due to maternal reinfection during pregnancy. Arch Pediatr. 2011 Jul;18(7):761-63. Disponible en: http://linkinghub.elsevier.com/retrieve/pii/S0929-693X(11)00183-7

  7. Barbosa B, Silva D, Costa I, Mineo J, Ferro E. BeWo trophoblast cell susceptibility to Toxoplasma gondii is increased by interferon-ã, interleukin-10 and transforming growth factor-â1. Clin Exp Immunol. 2008 March;151(3):536-45.

  8. Cañedo Solares I, Ortiz Alegría LB, Figueroa Damián R, Bustos Bahena ML, González Henkel H, Calderón Segura E, et al. Toxoplasmosis in pregnancy: determination of IgM, IgG and avidity in filter paper-embedded blood. J Perinatol. 2009 Oct;29(10):668-72. Disponible en: http://www.nature.com/jp/journal/v29/n10/full/jp200979a.html

  9. Year H, Filisetti D, P. Bastien P, Ancelle T, Thulliez P, Delhaes L: Multicenter Comparative Evaluation of Five Commercial Methods for Toxoplasma DNA Extraction from Amniotic Fluid. J Clin Microbiol. 2009 December;47(12):3881-6.

  10. Foulon W, Pinon JM, Stary-Pedersen B, Pollak A, Lappalainen M, Decoster A, et al. Prenatal diagnosis of congenital toxoplasmosis: a multicenter evaluation of different diagnostic parameters.Am J Obstet Gynecol. 1999 Oct;181(4):843-7. Disponible en: http://preview.ncbi.nlm.nih.gov/pubmed/10521739

  11. Boothroyd J. Toxoplasma gondii: 25 years and 25 major advances for the field. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford CA 94305-5124, USA. Int J Parasitol. 2009 July 1;39(8):935-46.

  12. Montoya JG, Liesenfeld O. Toxoplasmosis. Department of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA. The Lancet 2004 Jun 12;363(9425):1965-76.

  13. Rima McLeod R, Francois Kieffer F, Mari Sautter M, Hosten T, Pelloux H. Why prevent, diagnose and treat congenital toxoplasmosis? Mem Inst Oswaldo Cruz. 2009 March;104(2):320-44.

  14. Valentini P, Annunziata M, Angelone D, Masini L, De Santis M, Ranno O, et al. Role of spiramycin/cotrimoxazole association in the mother-to-child transmission of toxoplasmosis infection in pregnancy. European Journal Of Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology [serial on the Internet]. (2009 Mar), [cited August 15 2011];28(3):297-300. Disponible en: MEDLINE with Full Text. Available at: http://search.ebscohost.co/login.aspx?directm=true&db=mnh&AN=18716804&lang =es&site=ehost-live

  15. Berrebi A, Assouline C, Bessières M-H. Long-term outcome of children with congenital toxoplasmosis. Am J Obstet Gynecol. 2010;203(552):1-6.




2020     |     www.medigraphic.com