2015, Number 2
Med Int Mex 2015; 31 (2)
Antecedentes: las concentraciones séricas de CKBB se incrementan rápidamente posterior a daño cerebral y pueden alcanzar 30 a 40 veces por arriba del valor control. Se considera factor diagnóstico y pronóstico en pacientes con mediciones seis horas poster
Gracia-Reyes C, Dávila-Sosa D, Rodríguez-Romero E, Castro-Serna D, Melchor-López A
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ABSTRACTBackground: Serum CKBB apparently increases rapidly after the brain damage and can reach 30-40 times above the control value. It has come to regard as a diagnostic and prognostic factor in patients with measurements 6 hours after the injury and then at 6 days. It is proposed an enzymatic marker to guide us to early diagnosis and final treatment of this disease.
Objective: To determine whether serum levels of CKBB › 22 IU/L allow the diagnosis of cerebral ischemic vascular disease.
Material and method: A prospective study in which 43 patients with diagnosis of ischemic stroke less than 12 hours were included; all were submitted to a determination of serum CKBB and cranial computed tomography scans on admission and at 72 hours. It was calculated sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), as well as ROC curves for determining cutoff CKBB and performing relative risk.
Results: Of the patients included, 53.4% were male, with a mean age of 59.4±19 years, 35% of patients had not comorbidities. In the comparison of the evaluated test with the reference test (cranial CT) sensitivity 38%, specificity 89%, PPV 80%, NPV 60% were obtained. With the area under the curve of 93% and OR 6.1.
Conclusions: A negative test of CK BB (‹22 IU/L) is useful to exclude the diagnosis of ischemic cerebral vascular disease.