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Ginecología y Obstetricia de México

Federación Mexicana de Ginecología y Obstetricia, A.C.
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2015, Number 04

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Ginecol Obstet Mex 2015; 83 (04)

Cervix adenocarcinoma in a virgin patient with negative human papillomavirus

González-Ballano I, Aragón-Sanz MA, Guardia-Dodorico L, Rojas Pérez-Ezquerra B
Full text How to cite this article

Language: Spanish
References: 13
Page: 240-246
PDF size: 711.45 Kb.


Key words:

Cervical carcinoma, adenosquamous adenocarcinoma, human papillomavirus.

ABSTRACT

Cervical cancer in virgin women is extremely rare. We present the case of a 36-year-old patient without any type of sexual contact with sensation of lump in external genitalia referring only irregular bleeding in the previous two months, finding in vaginal examination an indurated mass in vaginal introitus with result in the biopsy of adenosquamous adenocarcinoma. The evolution of the tumor was very aggressive in spite of trying palliative chemotherapy, and patient died two months after of diagnosis with lung, liver and brain metastases. Cervical human papillomavirus testing was negative. What unusual of these cases does not justify the cytology as the only method of screening for cervical cancer.


REFERENCES

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  2. Walboomers J, Jacobs M, Manos M, Bosch X, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189:12-19.

  3. Böhmer G, Van den Brule AJ, Brummer O, Meijer CL, Petry KU. No confirmed case of human papillomavirus DNA-negative cervical intraepithelial neoplasia grade 3 or invasive primary cancer of the uterine cervix among 511 patients. Am J Obstet Gynecol 2003;189(1):118-20.

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  5. Gottwald L, Korczynski J, Gora E, Kusinska R, et al. Clear cell adenocarcinoma of the uterine cervix in a 24-year-old woman. Case report and review of the literature. Arch Med Sci 2012;8(3):578-581.

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  9. Liebrich C, Brummer O, Von Wasielewsk R, Wegener G, et al. Primary cervical cancer truly negative for high-risk human papillomavirus is a rare but distinct entity that can affect virgins and young adolescents. Eur J Gynaec Oncol 2009;3:45-48.

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Ginecol Obstet Mex. 2015;83