Cruz DG, García PDC

Language: Spanish
References: 14
Page: 70-78
PDF size: 93.81 Kb.

ABSTRACT

Neurodegenerative diseases are a main problem in today's society, the causes are not well defined, however, in a modern scientific world, the search for causes and solutions have led us to create a strong relationship between viruses and these diseases. There are viruses that help us in our search for genetically combat neurodegenerative diseases, and others apparently trigger physiological changes that culminate in the emergence of these same diseases.Among the virus we can find the Influenza A virus, Herpes Simplex Type 1, Adenovirus, Cytomegalovirus and Picornavirus. For these reasons, the issue becomes of great scientific importance, since knowledge of this area is becoming more essential nowadays, so we seek to inform about the latest developments in these areas.

REFERENCES

1. Ropper AH, Samuels MA. Degenerative Diseases of the Nervous System. En Ropper AH, Samuels MA. Adams & Victor's Principles of Neurology. 10ed; 2014

2. Life Science Weekly.Parkinson's disease; Study shows how Parkinson's disease protein acts like a virus. [En línea]2013 [Citado 2014 May 15].Disponible en: http://www.biocompare.com/Life-Science-News/135945-Study-Shows-How- Parkinson-s-Disease-Protein-Acts-Like-A-Virus/.

3. Du Y, Zhang X, Tao Q, Chen S, Le W. Adeno-Associated Virus Type 2 Vector- Mediated Glial Cell Line-Derived Neurotrophic Factor Gene Transfer Induces Neuroprotection and Neuroregeneration in a Ubiquitin-Proteasome System Impairment Animal Model of Parkinson's Disease. Neuro - Degenerative Diseases. 2013;11(3):113-28.

4. Shimada M, Abe S, Takahashi T, Shiozaki K, Okuda M, Mizukami H, et al. Prophylaxis and Treatment of Alzheimer's Disease by Delivery of an Adeno- Associated Virus Encoding a Monoclonal Antibody Targeting the Amyloid Beta Protein. PLoS One. 2013;8(3):1-8.

5. Sah DWY, Aronin N. Oligonucleotide therapeutic approaches for Huntington disease. J Clin Invest. 2011;121(2):500-7.

6. Professional Services Close Up. The ALS Association Announces Grants to Investigate the Causes of and Treatments for Lou Gehrig's disease. [En línea] 2014 [Citado 2014 Feb 15]. Disponible en: http://www.alsa.org/news/media/pressreleases/ new-grants-feb-2014.html.

7. Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, et al. Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial. The Lancet. 2014;383(9923):1138-46.

8. Miklossy J. Emerging roles of pathogens in Alzheimer disease. Expert Reviews in Molecular Medicine. 2011;13:34-e30.

9. Wansbrough G. Strong enterovirus, Lou Gehrig's link found: virus found in spinal cords of ALS patients. Medical Post. 2000;36(9):58.

10. Rohn TT, Catlin LW. Immunolocalization of Influenza A Virus and Markers of Inflammation in the Human Parkinson's Disease Brain. PLoS One. 2011;6(5).

11. Forsayeth J, Bankiewicz KS, Aminoff MJ. Gene therapy for Parkinson's disease: where are we now and where are we going? Expert Review of Neurotherapeutics. 2010; 10(12):1839-45.

12. BiotechWeek. Patent Issued for Recombinant Adeno-Associated Virus Vector for Treatment of Alzheimer Disease.[En línea] 2012 [Citado 2013Dic 12] Disponible en: http://www.highbeam.com/doc/1G1-311744143.html.

13. Wozniak MA, Frost AL, Preston CM, Itzhaki RF. Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1. PLoS One. 2011;6(10):1-15.

14. Cai Z, Zhao B, Ratka A. Oxidative Stress and beta]-Amyloid Protein in Alzheimer's Disease. Neuromolecular Medicine. 2011;13(4):223-50.