medigraphic.com
ISSN 2007-6800 (Print)

2014, Number 3

<< Back Next >>

Rev Mex Traspl 2014; 3 (3)

Kidney transplantation outcomes between spousal: 10-year experience in a Mexican center

Martínez-Mier G, Lara-Gutiérrez J, García-Esquina JL, Alvarado-Arenas R, Méndez-López MT, Budar-Fernández LF, Soto-Miranda E, Hernández-Maldonado EJ, Trujillo-Martínez MF, Uscanga-Montesano A, González-Velázquez F

Language: Spanish
References: 12
Page: 90-94
PDF size: 299.66 Kb.


ABSTRACT

Background: Spousal donation has become an important source of donor kidneys. We examined our results between spousal donors and living related kidney transplantation. Methods: From 02/03-03/13 twenty seven spouse donor kidney transplants were performed. They were compared with an age/sex matched living related (siblings) kidney transplantation group (n = 48). Outcomes were: 1-year acute rejection, graft function, patient/graft survival. Results: 63% patients were male. Mean age was 37.2 ± 9.8 years. Recipient BMI was 26.3 ± 4.2 kg/m2. 59.3% were on PD. Mean time of dialysis was 29.2 ± 20.2 months. 59.3% donor were female, donor BMI was 26.5 ± 2.5 kg/m2. There was no differences between spousal donors and siblings in sex, age, BMI, etiology, dialysis, donor sex and donor BMI. Spousal donors have higher eGFR (MDRD) (125.4 ± 14.3 mL/min) than siblings (116.3 ± 15 mL/min) (p = 0.01). Basiliximab induction was used in 100% spouse donors and 93.8% in siblings (p = ns). 1-year acute rejection was 18.8% in spousal donor and 4.2% in siblings (p = ns). One and 5-year eGFR by MDRD were similar (1-year: 61.9 ± 25.8 mL/min spouse versus 67.6 ± 22.9 mL/min siblings) (5-year: 51.7 ± 17.2 spouse versus 61.8 ± 28.6 mL/min) (p = ns). 10-year patient survival was 90% and control group 95% (p = ns). Uncensored 10-year graft survival was 89% in spouse donors and 79% in siblings (p = ns). Conclusions: Excellent long-term transplant outcomes are obtained in transplant from spousal donors compared to living related donors. Spouse should be encouraged as living donors.


REFERENCES

  1. http://www.cenatra.salud.gob.mx/interior/trasplante_estadisticas.html

  2. Ivanovski N, Popov Z, Kolevski P, Cakalaroski K, Masin J, Zafirovska K. Living emotionally related renal transplantation (LERT)-single center experience in the Balkans. Ann Transplant. 2004; 9 (2): 48-49.

  3. Tang S, Lui SL, Lo CY, Lo WK, Cheng IK, Lai KN et al. Spousal renal donor transplantation in Chinese subjects: a 10 year experience from a single centre. Neprhol Dial Trasplant. 2004; 19 (1): 203-206.

  4. Mukherjee A, Kekre NS, Gopalakrishnan G. The spouse as a donor in renal transplants. Saudi J Kidney Dis Transpl. 2006; 17 (1): 77-81.

  5. Roozbeh J, Mehdizadeh AR, Izadfar MA, Razmkon A, Salahi H, Malek-Hosseini SA. Comparison of spousal with other donor groups: study of a single center. Transplant Proc. 2006; 38 (2): 562-563.

  6. Karakayali F, Moray G, Colak T, Boyvat F, Haberal M. Results of kidney transplantation between spouses: a single center experience. Transplant Proc. 2007; 39 (4): 898-900.

  7. Sakai K, Okamoto M, Suzuki T, Yoshizawa A, Nobori S, Ushigome H et al. The excellence results of spousal kidney transplantation: experience in a Japanese single center. Transplant Proc. 2008; 40 (7): 2118-2120.

  8. Yoon HE, Song JC, Hyoung BJ, Hwang HS, Lee SY, Jeon YJ et al. Comparison of long term outcomes between spousal transplants and other living unrelated donor transplants: single-center experience. Nephron Clin Pract. 2009; 113 (4): c241-249.

  9. Gorgulu N, Caliskan Y, Yelken B, Turkmen A. Outcomes of renal transplants from spousal donors: 25 years of experience at our center. Int J Artif Organs. 2010; 33 (1): 40-44.

  10. Solak I, Sezer TO, Toz H, Tatar E, Isayev C, Firat O et al. Spousal versus living unrelated renal transplantation: a retrospective analysis of allograft outcomes. Transplant Proc. 2012; 44 (6): 1710-1712.

  11. Ishikawa N, Yagisawa T, Sakuma Y, Fujiwara T, Kimura T, Nukui A et al. Kidney transplantation of living unrelated donor-recipient combinations. Transplant Proc. 2012; 44 (1): 254-256.

  12. Stoves J, Lindley EJ, Barnfield MC, Burniston MT, Newstead GC. MDRD equation estimates of glomerular filtration rate in potential living kidney donors and renal transplant recipients with impaired graft function. Nephrol Dial Transplant. 2002; 17 (11): 2036-2037.




2020     |     www.medigraphic.com