2015, Number 1
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ABSTRACTInfections in SLE (systemic lupus erythematosus) are responsible of 40-50% of the morbility and mortality of this disease. The patients with SLE are more susceptible to the development of infections than non-SLE people. This increased susceptibility obeys to genetic factors, factors inherent to the disease (intrinsic) and the effects of immunosupressant drugs. The risk factors that promote the presentation of SLE co-infection are grouped as follows: 1) clinical features of the patient, 2) genetic factors, and 3) pharmaceutic treatment. The increased morbility of infections in patients with SLE is due mainly to the mechanism of action of the drug used. Up to 37% of the patients treated with ciclophosphamide develop a serious infection, which makes this medication the one with the highest association to infections. Bacterial infections are the most frecuent, and the most common are caused by Staphylococus aureus, Escherichia coli, Klebsiella sp. and Pseudomona sp. The most frecuent locations are the respiratory and urinary systems, and the skin. We reviewed the literature to determine the main risk factors implicated in the development of infections in SLE, as well as the physiopatologic description.
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