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Órgano Oficial de la Asociación Mexicana de Hepatología
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2014, Number 6

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Ann Hepatol 2014; 13 (6)

Adenovirus hepatitis presenting as tumoral lesions in an immunocompromised patient

Putra J, Suriawinata AA
Full text How to cite this article

Language: English
References: 5
Page: 827-829
PDF size: 156.39 Kb.


Key words:

Viral hepatitis, Acute liver injury, Liver biopsy, Imaging studies, Cidofovir.

ABSTRACT

A 59-year-old man with T-cell prolymphocytic leukemia on alemtuzumab presented with neutropenic fever, intermittent nausea, and multiple ill-defined low attenuation foci in the liver on abdominal computed tomography scan which were suspicious for metastatic disease. Histological examination revealed the diagnosis of adenovirus hepatitis. Patient responded well to cidofovir. Adenovirus hepatitis is a rare but important entity to be considered by the clinicians, radiologists, and pathologists. Timely diagnosis and appropriate management are essential to improve the prognosis of adenovirus hepatitis in immunocompromised patients.


REFERENCES

  1. Iyer A, Mathur R, Deepak BV, Sinard J. Fatal adenoviral hepatitis after rituximab therapy. Arch Pathol Lab Med 2006; 130: 1557-60. Figure 2. Biopsy of one of the lesions showed hepatocytes with enlarged and dark smudge cells which were characteristic of adenovirus infections, H&E (x 200). Figure 3. Diffuse positive immunostaining for adenovirus antibody confirmed the diagnosis, adenovirus antibody (x 200). 829 Adenovirus hepatitis presenting as tumoral lesions. , 2014; 13 (6): 827-829

  2. Ronan BA, Agrwal N, Carey EJ, De Petris G, Kusne S, Seville MT, Blair JE, et al. Fulminant hepatitis due to adenovirus. Infection 2014; 42: 105-11.

  3. Wang WH, Wang HL. Fulminant adenovirus hepatitis following bone marrow transplantation. Arch Pathol Lab Med 2003; 127: 246-8.

  4. Mortele KF, Segatto E, Ros PR. The infected liver: radiologic- pathologic correlation. Radiographics 2004; 4: 937-55.

  5. Suriawinata AA, Thung SN. Acute and chronic hepatitis. Semin Diagn Pathol 2006; 23: 132-48.




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C?MO CITAR (Vancouver)

Ann Hepatol. 2014;13