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2015, Number 3

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Rev Med MD 2015; 6.7 (3)

Association between dyslipidemia, central obesity, subcutaneous fat and metabolic syndrome in western Mexican mestizos

Navarro-Hernández RE, Flores-Alvarado LJ, Madrigal-Ruiz PM, Aguilar-Aldrete ME, Ruiz-Mejía MR, González-Romero E, Ramírez-García SA

Language: Spanish
References: 11
Page: 181-188
PDF size: 671.34 Kb.


ABSTRACT

Introduction. Obesity is most common and multifactorial feature with highest prevalence in the pathophysiology of metabolic syndrome. It is characterized by dyslipidemia, adipose tissue increase and other metabolic alterations. Our objective was to determine the incidence of dyslipidemia and metabolic syndrome in obese subjects. Establish a relation between the concepts above with central obesity and subcutaneous fat in mestizo population of western Mexico.
Material y Methods. A transversal study included 405 individuals. The following parameters were evaluated: body mass index using electrical bioimpedance and waist-to-hip ratio, each of them was classified according to the World Health Organization criteria. We determined serum glucose, lipid profile, subscapular, bicipital, tricipital,and suprailiac skinfolds, and mid-upper arm circumference. Student's T test, ANOVA and Pearson's correlation coefficient were used for statistical analysis.
Results. The study group included 405 individuals of a population between 18 and 76 years old (x=38+13-5 years). Classification by sex included 2 274 women (68%) and 131 men (32%). Body mass index groups included: normal weight (NW, BMI ‹24.9 kg/m2 ) 40%, n=163, overweight (OW, BMI 25-29.9 kg/m2 ) 38%, n=153 and obesity (OB, BMI ›30kg/m2 ) 22%, n=89. Triglyceride, DHL and ApoA1 levels in obese and overweight individuals were different when compared to normal weight subjects (119 and 78; 3.2, 162, 36, 114, vs. 113 and 71 mmHg; 0.3 mg/L, 122, 46, 128 mg/dL respectively. Fat percentage correlates with systolic blood pressure, total cholesterol, c-LDL and waist and hip circumference.
Discussion. The obese group included cardiovascular risk factors, dyslipidemia and central obesity. Our results suggest that the presence of dyslipidemias favor central distribution of body fat, increase in total cholesterol levels and c-LDL, which are associated to a positive body fat balance.


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