López GM, Rodríguez PU, López HSM, Lapido PS, Baldoquin RW

Language: Spanish
References: 19
Page: 516-527
PDF size: 181.65 Kb.

ABSTRACT

Objective: to describe the clinical characteristics of Fuchs' endothelial corneal dystrophy in the families under study.
Methods: observational, descriptive and cross-sectional study of families with Fuchs' corneal dystrophy diagnosed at "Ramón Pando Ferrer" Cuban Institute of Ophthalmology from 2008 to 2011. The study variables were clinical stage of the disease, depth of anterior chamber and iridocorneal angle, intraocular pressure, axial length, corneal thickness, endothelial cell density, pleomorphism and polymegatism. The variables were summarized using percentage absolute and relative frequencies. For assessing the ratio of the cell density and pachymetry, a nonparametric bivariate correlation analysis was made.
Results: the patients with Fuchs' endothelial corneal dystrophy were mostly in the clinical stages I and II, accounting for 50 % of the newly diagnosed patients and 60 % of the previously known ones. The amplitude of the anterior chamber was normal in 51,9 %, the iridocorneal angle was narrow in 55,6 %. Intraocular pressure was normal in 66,7 % and axial hypermetropia was found in 55,6 % of cases with corneal dystrophy. No significant association was found between the corneal thickness and cell density, but it was between pleomorphism and polyimegathism in 100 % of patients and in more than 50 % of the direct descendants.
Conclusions: the variables proved to be important in characterizing the disease as well as in pointing endothelial damages among non-sick descendants. This aspect should be considered on the follow-up period.

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