medigraphic.com
ISSN 1561-3070 (Electronic)

2014, Number 4

<< Back Next >>

Rev Cub Oftal 2014; 27 (4)

Schnyder dystrophy

Pérez PZ, Escalona LET, Castillo PAC, Jareño OM, Cuevas RJ

Language: Spanish
References: 11
Page: 633-639
PDF size: 157.24 Kb.


ABSTRACT

Among the stromal dystrophies, we may find Schnyder dystrophy that is characterized by its bilateral and progressive nature. Diagnosis is relatively simple when presented with choresterol crystals and phospholipids. The histological study and the confocal microscopy confirm the diagnosis. We reported two female patients with Schnyder dystrophy, who went to the ophthalmological service and stated decreased vision and changed eye color. The clinical and confocal microscopy findings confirmed the diagnosis of Schnyder dystrophy. This entity is characterized by the presence of crystals into the central anterior stroma with annular distribution and related to lipoid arch and haze in the mid-periphery. The excimer laser photokeratectomy to manage the anterior stroma and the penetrating keratoplasty for more advanced cases are the best therapeutic tools to treat this condition.


REFERENCES

  1. Warburg M, Møller HU. Dystrophy: a revised definition. J Med Genet [Internet]. 1989 [citado 10 de febrero de 2002];26(12):769-71. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1015758/

  2. Weiss J, Moller HU, Lisch W, Kinoshita S, Aldave AJ, Belin MW, et al. The IC3D classification of the corneal dystrophies. Cornea [Internet]. 2008 [citado 10 de junio de 2012]; Suppl. 2:S1-83. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/19337156

  3. American Academy of Ophthalmology. External diseases and cornea. In: Sutphin JE, ed. Basic and Clinical Sciences Course 2007-2008. San Francisco, CA: American Academy of Ophthalmology; 2007:305-29.

  4. Centellas-Vargas WR, Velasco R, Baca O, Babayán A. Microscopia confocal en distrofias corneales. Rev Mex Oftalmol [Internet]. 2009 [citado 20 de febrero de 2013];83(1):262-34. Disponible en: http://www.medigraphic.com/pdfs/revmexoft/rmo-2009/rmo091f.pdf

  5. Wörner N, Goldblum D, Miserez A, Flammer J, Meyer P. Clinical and pathological features of a non-crystalline form of Schnyder corneal dystrophy. Graefe's Archive for Clinical and Experimental Ophthalmology [Internet]. 2012 [citado 18 de junio de 2014];250(8):1241-3. Disponible en http://www.ncbi.nlm.nih.gov/pubmed/22411127

  6. Yellore VS, Khan MA, Bourla N, Rayner SA, Chen MC, Sonmez B, et al. Molecular Vision [Internet]. 2007 [citado: 10 de mayo de 2014];13:1777-82. Disponible en: http://www.molvis.org/molvis/v13/a198/

  7. Weiss JS. Schnyder corneal dystrophy. Curr Opin Ophthalmol [Internet]. 2009 [citado: 10 de mayo de 2014];20(4):292-8. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/19398911

  8. Huda AG, Jawahir YM, Arif OK. Schnyder Corneal dystrophy in a Saudi Arabian family with heterozygous UBIAD1 mutation (p.L121F). Middle East Afr J Ophthalmol [Internet]. 2011 [citado 28 de enero de 2014];18(1):61-4. Disponible en: http://www.meajo.org

  9. Yang J, Chun L, Wang L. A novel UBIAD1 mutation identified in a Chinese family with Schnyder crystalline corneal dystrophy. Mol Vis [Internet]. 2009 [citado 10 de Julio de 2013];15:1463-9. Disponible en: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718742/

  10. Ciancaglini M, Carpineto P, Doronzo E, Nubile M, Zuppardi E, Mastropasqua L. Morphological evaluation of Schnyder's central crystalline dystrophy by confocal microscopy before and after phototherapeutic keratectomy. J Cataract Refract Surg [Internet]. 2001 [citado 10 de febrero de 2012];27(11):1892-5. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/11709268

  11. Mehta JS, Vithana EN, Venkataraman D, Venkatraman A, Poh R, Beuerman RW, et al. Analysis of conjunctival fibroblasts from a proband with Schnyder corneal dystrophy. Mol Vis [Internet]. 2008 [citado 10 de febrero de 2012];14:1277-81. Disponible en: http://www.molvis.org/molvis/v14/a151




2020     |     www.medigraphic.com