Rován M, Borche L

Language: Spanish
References: 17
Page: 150-155
PDF size: 51.70 Kb.

ABSTRACT

The aim of this study was to evaluate a new, transferrin-albumin index proposed as a valuable diagnostic tool in iron metabolism by P. Cacoub et al. Since transferrin and albumin are liver sinthetized proteins in paralel form, the difference observed between them is due to a hypersynthetic response of transferrin to iron depletion. Mean serum values for both proteins was considered as 100%. In order to evaluate the proposed index, Total Iron Binding Capacity and serum albumin, by bromocresol green method was used. From the selected 384 patients and considering ferritin ‹ 26 ng/mL as gold standard value for stores iron depletion, Transferrin Albumin Difference ›= 28% and /or Transferrin Saturation Index minnus than 20% showed a Negative Predictive Value of 98% and a Positive Predictive Value of 46%. Finally, in several cases Transferrin Albumin Difference was the only suspicious marker for the ferropenic status in situations associated to a high ferritin value (cytolitic or inflamatory pathologies).

REFERENCES

1. Gambino R. Serum transferrina (total iron binding capacity) in evaluation of iron status. (Letter). Clinical Chemistry 1996; 42: 2053.

2. Worwood M. The laboratory assessment of iron status-an update. Clinic Chemical Acta 1997; 259: 3-23.

3. Cacoub P, Thiolières JM, Alexandre JA. Profil protéique et carence martiale: intérèt du couple albumine-transferrine. Revue Medicine Interne 1996; 17: 627-634.

4. Martell M, Fescina R, Martínez G. Metodología de la investigación científica. Primera edición, Montevideo: Oficina del Libro AEM, 1997.

5. Gouyatt GH, Patterson C, Mahmoud A et al. Diagnosis of iron deficiency anaemia in the elderly. American Journal of Medicine 1990; 88: 205-209.

6. Lee JG, Sahagun G, Oehlke MA et al. Serious gastrointestinal pathology found in patients with serum ferritin values < 50 ng/mL. American Journal of Gastroenterology 1998; 93: 772-776.

7. Intragumtorchnai T, Rojnukkarin PT et al. The role of serum ferritin in the diagnosis of iron deficiency anaemia in patients with liver cirrhosis. Journal of Internal Medicine 1998; 243: 233-241.

8. Philippe P, Ruivard M. Fer et inflammation. Revue du praticien 2000; 50: 961-965.

9. Hallberg L, Bengtsson C, Lapidus L et al. Screening for iron deficiency: an analysis based on bone-marrow examinations and serum ferritin determinations in a population sample of women. British Journal of Haematology 1995; 85: 787-798.

10. Ferguson BJ, Skikne BS, Simpson KM et al. Serum transferrin receptor distinguishes the anaemia of cronic disease from iron deficiency anaemia. Journal of Laboratory and Clinical Medicine 1998; 119: 385-390.

11. Mast AE, Blinder MA, Gronowski AM et al. Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clinical Chemistry 1998; 44: 45-51.

12. Kalantar-Zadeh K, Höffken B, Wünsch H et al. Diagnosis of iron deficiency anaemia in renal failure patients during the post-erythropoietin era. American Journal of Kidney Diseases 1995; 26: 292-299.

13. Allegra V, Mengozzi G, Vasile A et al. Iron deficiency in maintenance hemodialisis patients. Nephron 1991; 57: 175-182.

14. Campistrús N, Dibello N, Álvarez I et al. Evolución del metabolismo férrico de pacientes en hemodiálisis periódica tratados con eritropoyetina. Archivos de Medicina Interna 1997; 19: 59-63.

15. Witte DL, Kaemer DF, Johnson GF et al. Prediction of bone marrow findings from test performed on peripheral blood. American Journal of Clinical Pathology 1986; 85: 202-206.

16. Witte DL. Can serum ferritin be effectively interpreted in the presence of the acute phase response? Clinical Chemistry 1991; 37: 484-485.

17. Vernet M. Exploration du statut martial. Revue du Praticien 2000; 50: 950-956.