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2001, Number 3

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Rev Mex Patol Clin Med Lab 2001; 48 (3)

Antiphospholipid antibodies and Z protein

Perdomo BS, Forastiero R, Martinuzzo M, Kordich L

Language: Spanish
References: 7
Page: 166-169
PDF size: 28.19 Kb.


ABSTRACT

Protein Z (PZ) constitutes a plasmatic protein, vitamin K dependent. It joins thrombin, promoting its link to phospholipidic vesicles, getting joined by itself to these surfaces in the presence of calcium. We have measured plasmatic PZ concentration in patients with anti- phospholipidic (aPL) antibodies. 53 patients with aPL were studied, 33 of them were given, besides PZ, antiprothrombin antibodies (anti-II) and antibeta 2 glicoprotein 1 (ab2GP1). The test group was composed by 36 normal people. Patients with aPL presented diminished levels of PZ, with a statistical significance of p ‹ 0.0001. Levels of PZ were found to be diminished, apart from the presence or absence of anti-II or antibeta 2 glicoprotein. We conclude that patients with aPL present decreased levels of plasmatic PZ, without any relationship with antigenic specificity of antiphospholipidic antibodies. It is already unknown if this alteration may be due to a quick protein depuration, to its synthesis inhibition or to specific anti-Pz antibodies presence.


REFERENCES

  1. Forastiero R, Martinuzzo M, Serrato G, Kordich L, Carreras L. Relation of anti-B2GP1 and anti prothrombin antibody to thrombosis and pregnancy loss in patients with anti-prothrombin antibodies. Thromb and Haemost 1997; 78: 1008-1015.

  2. Harris E. The second international anticardiolipin standarization workshop the Kingston Antiphospholipid Antibody Study (KAPS Group). Am J Clin Pathol 1990; 94: 476-484.

  3. Ham X, Fielher R, Broze G Jr. Interaction of protein Z dependent plasma proteasa inhibitor. Proc Natl Acad Sci USA 1998; 95 (16): 9250-9255.

  4. Hogg P, Stanflo J. Interaction of vitamin K-dependent protein Z with thrombine. J Biol Chem 1999; 216 (17): 10953-10958.

  5. Martinuzzo M, Forastiero R, Carreras L. Antibeta 2 Glicoprotein 1 Antibodies: Detection and association with thrombosis. Br J of Haem 1995; 89: 397-402.

  6. Rand Jacob, Xiao-Xuan Wu. Thromb and Haemost 1999; 82 (2): 669-655.

  7. Stéffano de Perdomo B. El Síndrome antifosfolipídico. Tendencias 1997; (11): 61-68.




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