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2015, Number 1

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Rev Mex Pediatr 2015; 82 (1)

Chronic kidney disease in children, a complication of obesity and the metabolic syndrome

Ortega-Cortés R

Language: Spanish
References: 25
Page: 18-23
PDF size: 307.88 Kb.


ABSTRACT

Childhood obesity prevalence tripled in recent decades become a global epidemic. Complications of this problem in children as hypertension, dyslipidemia, insulin resistance, inflammation and endothelial damage are part of the metabolic syndrome (MS). Little attention to relationship of overweight and renal disorders early, despite the increase in prevalence of chronic kidney disease (CKD) in adults and children, that could be associated to the increase in obesity is paid. It is hypothesized that MS components interact increasing cytokine production, generating chronic state of low-grade inflammation, which may play central role in cardiovascular complications such as ERC. Recently chronic inflammation is recognized as responsible for morbidities, such as cytokines adipose tissue which induced inflammatory changes in glomeruli of patients with kidney disease associated with obesity. The purpose of the review is to discuss the association between obesity, metabolic syndrome and early kidney damage in children.


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