Bonifaz A, Carrasco-Gerard E, Palacios-López C, Araiza J

Language: Spanish
References: 17
Page: 11-15
PDF size: 267.92 Kb.

ABSTRACT

An open-design, prospective, non-comparative study was conducted to evaluate the efficacy and safety of fluconazole intermittent treatment of black-dot Tinea Capitis. Treatment consisted of oral fluconazole at doses of 3-6 mg/kg/week. Clinical and mycological control examinations were performed at baseline and the end of treatment (4, 6, or 8 weeks); a follow-up visit took place at 30 days after the last medication. All cases were children, 10 boys and 8 girls with an average of 7.3 years old. All cases were confirmed micologically: 14 had ecto-endothrix hair-parasitation; 3 endothrix and 1 microide; corresponding to 14 cases due to M. Canis, 3 to T. Tonsurans and 1 to T. Mentagrophytes.
7/18 (38%) cases had failed to different treatments. 17/18 cases were administrated 50 mg/week and one 100 mg/week. Of the treatment’s schemes: 14/18 cases (77.7%) cured with 4 doses; 3/18 cases (16.6%) with 6 doses and only one required 8 doses. At the final follow-up visit (30 days), all the cases (100%) cured clinical and mycological. We concluded that the administration of intermittent fluconazole (weekly) was effective, achieving clinical and mycological cure of 94.3%. The medication was well tolerated, and only one case presented side effect attributable to fluconazole with a moderate headache and not required discontinuation of the medication. We consider that the fluconazole intermittent treatment is an excellent alternative of therapy to Tinea Capitis.

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