Alarcón-Sotelo A, Espinosa-Sevilla A, Díaz-Greene E, Rodríguez-Weber FL

Language: Spanish
References: 0
Page: 296-300
PDF size: 387.09 Kb.

ABSTRACT

Diabetes mellitus currently shows an increase in incidence, which has positioned itself as a major global health problem, with the consequent development of secondary renal disease due to alterations in kidney glucose homeostasis. The mechanisms of regulation of renal glucose metabolism have been studied in recent years, in order to develop targeted therapies that act on them as an additional treatment measure to those already known in the management of diabetes mellitus. The challenge has been to determine how to influence the pathophysiology of the disease without overstretched renal compensation mechanisms. Based on this, there are known drugs that act on receptors and glucose transporters in the kidney, and in the coming years it is expected to maximize the focus of these therapies alongside the development of greater understanding of renal physiology.