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Colegio de Medicos y Cirujanos República de Costa Rica

2015, Number 614

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Rev Med Cos Cen 2015; 72 (614)

Distrofia de Fuchs

Camacho EO, Gómez QA

Language: Spanish
References: 11
Page: 195-200
PDF size: 60.87 Kb.


ABSTRACT

Fuchs endothelial corneal dystrophy is a primary, progressive disorder characterized by loss of the corneal endothelium cells that results in corneal edema and loss of vision. The clinical course usually spans 10–20 years, the initial stages typically begin in the fifth through seventh decades of life and are characterized by progressive accumulation of focal excrescences, termed “guttae,” and thickening of Descemet’s membrane, a collagen-rich layer secreted by endothelial cells. Eventually, there is loss of endothelial cell density and functionality as the “pump” of the cornea, causing corneal edema.


REFERENCES

  1. Aldave A., Han J, Frausto R. Genetics of the Corneal Endothelial Dystrophies: An Evidence- Based Review. Clin Genet. 2013 August ; 84(2).

  2. Bruinsma M., Tong C., Melles G. What does the future hold for the treatment of Fuchs endothelial dystrophy; will ‘keratoplasty’ still be a valid procedure?. Nature Publishing Group Eye (2013) 27, 1115–1122

  3. Eghrari A. Fuchs’ corneal dystrophy. Expert Rev Ophthalmol. 2010 April ; 5(2): 147–159.

  4. Elhalis H., Azizi B., Jurkunas U. Fuchs Endothelial Corneal Dystrophy. Ocul Surf. 2010 October ; 8(4): 173–184.

  5. Hamill C., Schmedt T. Fuchs endothelial cornea dystrophy: a review of the genetics behind disease development. Semin Ophthalmol. 2013 ; 28(0): 281–286

  6. Hemadevi B, Srinivasan M, Arunkumar J, Prajna NV, Sundaresan P. Genetic analysis of patients with Fuchs endothelial corneal dystrophy in India. BMC Ophthalmol 2010;10:3.

  7. Kopplin L., Przepyszny K., Schmotzer B. Relationship of Fuchs’ Endothelial Corneal Dystrophy Severity to Central Corneal Thickness. Arch Ophthalmol. 2012 April ; 130(4).

  8. Louttit M., Kopplin L., Igo R., A Multi-Center Study to Map Genes for Fuchs’ Endothelial Corneal Dystrophy: Baseline Characteristics and Heritability. Cornea. 2012 January ; 31(1): 26–35

  9. Nagarsheth M., Singh A., Schmotzer B. The Relationship between Fuchs’ Endothelial Corneal Dystrophy Severity and Glaucoma and/ or Ocular Hypertension. Arch Ophthalmol. 2012 November ; 130(11): 1384–1388.

  10. Ophthalmic Pathology and Intraocular Tumors, Section 4. Basic and Clinical Science Course. American Academy of Ophthalmology 2011-2012.

  11. Wojcik K., Kaminska A. Oxidative Stress in the Pathogenesis of Keratoconus and Fuchs Endothelial Corneal Dystrophy. Int. J. Mol. Sci. 2013, 14, 19294-19308




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