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2003, Number 2

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Dermatología Cosmética, Médica y Quirúrgica 2003; 1 (2)

Prophylactic effect of colchicine for keloids after surgical procedures

León TS, Ortega SA, Ramírez VR, Sánchez NLM

Language: Spanish
References: 51
Page: 79-88
PDF size: 203.42 Kb.


ABSTRACT

Background: Wound healing is the way to repair tissues after an injury or lost of tissue. This process take place with some events that we know as the Repair Cascade. This process can produce keloid and hypertrophic scars, due to a dermal fibroproliferative process that occurs following any trauma or surgery. The treatments of these conditions are not effective.
Objetive: We tried to demonstrate that colchicine could play a preventive role, decreasing the fibroblasts replication and the collagen synthesis.
Material and methods: We performed a double blind clinic assay in fifty patients prone to develop keloid or hypertrophyc scars. They received colchicine 1 mg/d/90 days or placebo, starting seven days after surgery.
Results: We found that the patients treated with colchicine were practically free of keloids, as compared with the placebo group in whom most of them develop keloid or hypertrophic scars.
Conclusions: Colchicine has a preventive effect in the formation of keloid and hypertrophic scars in patients prone to develop them.


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