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2003, Number 2

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Dermatología Cosmética, Médica y Quirúrgica 2003; 1 (2)

Chronic graft versus host disease: case report and review

Michel JA, Vega ME, Arenas R, Valdez MS, David PE

Language: Spanish
References: 11
Page: 107-110
PDF size: 191.25 Kb.


ABSTRACT

Graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation, and is relevant because GVHD is the main cause of morbidity and mortality amongst transplanted patients. We report a 19-year-old female patient with a history of acute lymphoblastic leukemia, 100% matched bone marrow transplantation and acute graft versus host disease. She came to our clinic two years after the transplant with a dermatosis affecting the entire skin body surface. She presented hyperpigmented and erythematous patches with an atrophic center and sclerodermic changes. On the dorsal aspect of the tongue white patches were present. Those conditions have been present for eight months. The skin biopsy showed a chronic lichenoid and sclerodermiform GVHD. Oral cultures confirmed candidiasis.
Graft versus host disease is a systemic disease, the skin is the first and the most frequently affected organ. The main risk factor for chronic GVHD is the precedent of an acute GVHD. The optimal treatment is the combined therapy of corticosteroids and cyclosporine.


REFERENCES

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