Rodríguez-Hernández H, Simental-Mendía LE, Bermúdez-Peña C, Zambrano-Galván G, Rodríguez-Morán M, Guerrero-Romero F

Language: English
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Dear Editor:
Because elevation of serum alanine aminotransferase (ALT) levels plays an important role in developing of type 2 diabetes (T2D), we evaluated whether the elevated ALT levels are associated with incident impaired fasting glucose (IFG) and T2D, in obese women.
Obese (body mass index [BMI] ≥ 30 kg/m²) nonpregnant women aged 20 to 65 years were enrolled in a cross-sectional study. Alcohol consumption ≥ 20 g per day, smoking, positive markers of viral or autoimmune hepatitis, any kind of medical treatment, previous diagnosis of acute or chronic liver disease, renal failure, glomerulopathies, neoplasia, cardiovascular disease, and intake of contraceptives or hepatotoxic drugs, were exclusion criteria. Waist circumference and total body fat were matched criteria. Elevate

REFERENCES

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2. Wannamethee SG, Lennon L, Shaper AG, Whincup PH. Hepatic enzymes, the metabolic syndrome and the risk of type 2 diabetes in older. Diabetes Care 2005; 28: 2913-18.

3. Hanley AJ, Williams K, Festa A, Wagenknecht LE, D’Agostino RB Jr, Haffner SM. Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study. Diabetes 2005; 54: 3140-47.