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Órgano Oficial de la Asociación Mexicana de Hepatología
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2012, Number 4

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Ann Hepatol 2012; 11 (4)

Pegylated interferon, but not conventional interferon therapy induced severe skin lesions

Zhengxiao L, Fanpu J, Yan Z, Jingang A, Zhenhui P
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Language: English
References: 6
Page: 570-571
PDF size: 83.83 Kb.


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Dear Editor:
Pegylation is an important technique that has greatly improved the pharmacologic profile of interferon. Compared with conventional interferon(IFN)-α injections, pegylated interferon (PEG-IFN) has a longer half-life allowing for once-weekly injections and superior antiviral efficacy in the treatment of hepatitis C when used in combination with ribavirin. However, cutaneous side effects had been reported more frequent with PEG-IFN. We present a patient with chronic hepatitis C (CHC) in whom PEG-IFN, but not conventional interferon therapy induced severe skin lesions at the sites of injection.


REFERENCES

  1. Reddy KR, Wright TL, Pockros PJ, Shiffman M, Everson G, Reindollar R, Fried MW, et al. Efficacy and safety of pegylated (40-kd) interferon alpha-2a compared with interferon alpha-2a in noncirrhotic patients with chronic hepatitis C. Hepatology 2001; 33: 433-8.

  2. Edwards IR, Aronson JK. Adverse drugs reactions: definitions, diagnosis, and management. Lancet 2000; 356: 1255-9.

  3. Dereure O, Raison-Peyron N, Larrey D, Blanc F, Guilhou JJ. Diffuse inflammatory lesions in patients treated with interferon alfa and ribavirin for hepatitis C: a series of 20 patients. Br J Dermatol 2002; 147: 1142-6.

  4. Lübbe J, Kerl K, Negro F, Saurat JH. Clinical and immunological features of hepatitis C treatment associated dermatitis in 36 prospective cases. Br J Dermatol 2005; 153: 1088-90.

  5. Hashimoto Y, Kanto H, Itoh M. Adverse skin reactions due to pegylated interferon alpha 2b plus ribavirin combination therapy in a patient with chronic hepatitis C virus. J Dermatol 2007; 34: 577-82.

  6. Veldt BJ, Schalm SW, Janssen HL. Severe allergic eczema due to pegylated alfa interferon may abate after switching to daily conventional alfa-interferon. J Clin Gastroenterol 2007; 41: 432.




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Ann Hepatol. 2012;11