2012, Number 3
Cardiac metastasis of hepatocellular carcinoma in a young non-cirrhotic patient, to the left ventricle
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ABSTRACTHepatocellular carcinoma (HCC) is the most common primary tumor of the liver. The most common extrahepatic metastatic sites are lung, abdominal lymph nodes and bone, while its cardiac metastasis is rare. Metastasis of HCC into the cardiac cavity is mostly caused by direct tumor invasion of vena cava inferior with continuous extension into the right cardiac cavity. Right heart metastasis without invasion of inferior vena cava, which may be caused by hematogenous spread of cancer cells, is rarely reported. This paper announces an unusual case of isolated involvement of left ventricle (LV) together with myocardial invasion of HCC. Our patient is known to be the first case with isolated HCC metastasis to the left ventricle. Strikingly, the patient was young and non-cirrhotic with negative serum HBsAg, and anti-HCV results
Katyal S, Oliver JH 3rd., Peterson MS, Ferris JV, Carr BS, Baron RL. Extrahepatic metastases of hepatocellular carcinoma. Radiology 2000; 216(3): 698-703.
Anwar AM, Nosir YF, Chamsi-Pasha MA, Ajam A, Chamsi- Pasha H. Right Atrial Metastasis Mimicking Myxoma in Advanced Hepatocellular Carcinoma. Echocardiography 2010; 27(1): 80-3.
Hong SS, Kim TK, Sung KB, et al. Extrahepatic spread of hepatocellular carcinoma: a pictorial review. Eur Radiol 2003; 13: p. 874-82.
Masci G, Magagnoli M, Grimaldi A, et al. Metastasis of hepatocellular carcinoma to the heart: a case report and review of the literature. Tumori 2004; 90: 345-7.
Atkins KA. Metastatic hepatocellular carcinoma to the heart. Diagn Cytopathol 2000; 23: 406-8.
Longo R, Mocini D, Santini M, et al. Unusual Sites of Metastatic Malignancy. Cardiac Metastasis in Hepatocellular Carcinoma. J Clin Oncol 2004; 22(24): 5012-3.
Kan CB, Chang RY, Chen CK. Isolated Right Ventricular Intracavitary Metastasis of Hepatocellular Carcinoma in a 74- year-old Woman. J Chn Med Assoc 2008; 71(6): 318-20.
Taoli B, Losada M, Holland A, Krinsky G. Magnetic resonance imaging of hepatocellular carcinoma. Gastroenterology 2004; 127: 144-52.
Craig JR, Peters RL, Edmondson HA, Omata M. Fibrolamellar carcinoma of the liver: a tumor of adolescents and young adults with distinctive clinicopathologic features. Cancer 1980; 46: 372-9.
Ward SC, Waxman S. Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. Semin Liver Dis 2011; 31(1): 61-70.
Trevisani F, D’Intino PE, Caraceni P, et al. Etiologic factors and clinical presentation of hepatocellular carcinoma. Differences between cirrhotic and noncirrhotic Italian patients. Cancer 1995; 75: 2220-32.
Sezaki H, Kobayashi M, Hosaka T, et al. Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection. J Gastroenterol 2004; 39: 550-6.
Kato Y, Tanaka N, Kobayashi K, Ikeda T, Hattori N, Nonomura A. Growth of hepatocellular carcinoma into the right atrium. Report of five cases. Ann Intern Med 1983; 99: 472-4.
Lei MH, Ko YL, Kuan PL, Lien WP, Chen DS. Metastasis of hepatocellular carcinoma to the heart: unusual patterns in three cases with antemortem diagnosis. J Formos Med Assoc 1992; 91: 457-61.