>Annals of Hepatology
>Year 2012, Issue 3
Guardigni V, Fabbri G, Grilli A, Contini C
Successful antiviral treatment of chronic hepatitis C in patients with rare comorbidities. Two case-reports
Ann Hepatol 2012; 11 (3)
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Antiviral therapy in patients suffering from chronic hepatitis C virus (HCV) infection and rare comorbidities
cannot be easily started, as it can reduce the likelihood of a good therapeutic response with an increased
frequency of side effects. We report two patients presenting unusual comorbidities associated with chronic
C hepatitis: one with the Ehlers-Danlos Syndrome (EDS), a rare genetic disease caused by a defect in collagen
synthesis, the other one with the Charcot Marie Tooth (CMT) disease, an uncommon but severe form
of demyelinating peripheral neuropathy. Both patients were successfully treated with pegylated Interferon
(Peg-IFN) and ribavirin (RBV) combined therapy, with the achievement of a sustained viral response
(SVR) and a low occurrence of adverse effects. Up to now there are no reports of patients suffering
from chronic C hepatitis associated with these uncommon but severe comorbidities treated with antiviral
therapy. In conclusion, in such clinical situations, anti-HCV therapy may be started and tailored, especially
if the patient is highly motivated and if optimal predictors of response (i.e. young age, favourable genotype
and low baseline viraemia) do exist.
||Charcot Marie Tooth Disease, Ehlers-Danlos Syndrome, Peg-Interferon, HCV.
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>Annals of Hepatology
>Year 2012, Issue 3