Entrar/Registro  
HOME SPANISH
 
Annals of Hepatology
   
MENU

Contents by Year, Volume and Issue

Table of Contents

General Information

Instructions for Authors

Message to Editor

Editorial Board






>Journals >Annals of Hepatology >Year 2012, Issue 3


Guardigni V, Fabbri G, Grilli A, Contini C
Successful antiviral treatment of chronic hepatitis C in patients with rare comorbidities. Two case-reports
Ann Hepatol 2012; 11 (3)

Language: Inglés
References: 20
Page: 404-408
PDF: 77.79 Kb.


Full text




ABSTRACT

Antiviral therapy in patients suffering from chronic hepatitis C virus (HCV) infection and rare comorbidities cannot be easily started, as it can reduce the likelihood of a good therapeutic response with an increased frequency of side effects. We report two patients presenting unusual comorbidities associated with chronic C hepatitis: one with the Ehlers-Danlos Syndrome (EDS), a rare genetic disease caused by a defect in collagen synthesis, the other one with the Charcot Marie Tooth (CMT) disease, an uncommon but severe form of demyelinating peripheral neuropathy. Both patients were successfully treated with pegylated Interferon (Peg-IFN) and ribavirin (RBV) combined therapy, with the achievement of a sustained viral response (SVR) and a low occurrence of adverse effects. Up to now there are no reports of patients suffering from chronic C hepatitis associated with these uncommon but severe comorbidities treated with antiviral therapy. In conclusion, in such clinical situations, anti-HCV therapy may be started and tailored, especially if the patient is highly motivated and if optimal predictors of response (i.e. young age, favourable genotype and low baseline viraemia) do exist.


Key words: Charcot Marie Tooth Disease, Ehlers-Danlos Syndrome, Peg-Interferon, HCV.


REFERENCIAS

  1. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Management of hepatitis C virus infection. J Hepatology 2011; 55: 245-64.

  2. Mecenate F, Pellicelli AM, Barbaro G, Romano M, Barlattani A, Mazzoni E, Bonaventura ME, et al. Club Epatologi Ospedalieri (CLEO) Group. Short versus standard treatment with pegylated interferon alfa-2A plus ribavirin in patients with hepatitis C virus genotype 2 or 3: the cleo trial. BMC Gastroenterology 2010; 10: 21.

  3. Bowden DS, Berzsenyi MD. Chronic hepatitis C virus infection: genotyping and its clinical role. Future Microbiology 2006; 1: 103-12.

  4. Germain DP. Clinical and genetic features of vascular Ehlers-Danlos syndrome. Annals of Vascular Surgery 2002; 16: 391-7.

  5. Lind J, Wallenburg HC. Pregnancy and the Ehlers-Danlos syndrome: a retrospective study in a Dutch population. Acta Obstetricia et Gynecologica Scandinavica 2002; 81: 293-300.

  6. Tassart S, Bernard P, Debieve F, Devylder M, Hubinont C. Dissection of renal artery aneurysm in a pregnant woman with Elhers-Danlos disease type IV. Journal de Gynécologie, Obstetrique et Biologie De La Reproduction 2006; 35: 275-9.

  7. Beighton P, De Paepe A, Steinmann B, Tsipouras P, Wenstrup R. Ehlers-Danlos syndromes: revised nosology, Villefranche. Am J Medical Genetics 1998; 77: 31-7.

  8. Iurassic S. Hypermobile syndrome: functional and aesthetic damages. Observations on 50 cases. La Medicina Del Lavoro 2004; 95: 223-32.

  9. Bacon BR, McHutchison JG. Treatment issue with chronic hepatitis C: special population and pharmacy strategies. The American Journal of Managed Care 2005; 11: 296-306.

  10. Stribling R, Sussman N, Vierling JM. Treatment of hepatitis C infection. Gastroenterology Clinics of North America 2006; 35: 463-86.

  11. Kamholz J, Menichella D, Jani A, Garbern J, Lewis RA, Krajewski KM, Lilien J, et al. Charcot-Marie-Tooth disease type 1: Molecular pathogenesis to gene therapy. Brain 2000; 123: 222-33.

  12. Shy ME. Charcot–Marie–Tooth disease: an update. Current Opinion in Neurology 2004; 17: 579-85.

  13. Irobi J, Van Impe K, Seeman P, Jordanova A, Dierick I, Verpoorten N, Michalik A, et al. Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. Nature Genetics 2004; 36: 597-601.

  14. Niemann A, Berger P, Suter U. Pathomechanisms of Mutant Proteins in Charcot-Marie-Tooth Disease. Neuromolecular Medicine 2006; 8: 217-42.

  15. Yoon MS, Obermann M, Dockweiler C, Assert R, et al. Sensory neuropathy in patients with cryoglobulin negative hepatitis C infection. J Neurology 2011; 258: 80-8.

  16. Nemni R, Sanvito L, Quattrini A, Santuccio G, Camerlingo M, Canal M. Peripheral neuropathy in hepatitis C virus infection with and without cryoglobulinaemia. J Neurology Neurosurgery and Psychiatry 2003; 74: 1267–71.

  17. Khiani V, Kelly T, Shibli A, Jensen D, Mohanty SR. Acute inflammatory demyelinating polyneuropathy associated with pegylated interferon á 2a therapy for chronic hepatitis C virus infection. World J Gastroenterology 2008; 14: 318-21.

  18. Santoro L, Manganelli F, Briani C, Giannini F, Benedetti L, Vitelli E, Mazzeo A, et al. HCV Peripheral Nerve Study Group. HCV Peripheral Nerve Study Group, Prevalence and characteristics of peripheral neuropathy in hepatitis C virus population. J Neurology Neurosurgery and Psychiatry 2006; 77: 626-9.

  19. Brannagan TH 3rd. Current treatments of chronic immune- mediated demyelinating polyneuropathies. Muscle & Nerve 2009; 39: 563-78.

  20. National Institute of Health. National Institutes of Health Consensus Development Conference Statement: Management of hepatitis C: 2002-June 10-12, 2002. Hepatology 2002; 36: S3-S20.






>Journals >Annals of Hepatology >Year 2012, Issue 3
 

· Journal Index 
· Links 






       
Copyright 2019